Thursday, April 2, 2015

Explaining the “Entourage Effect” in Cannabis

The Whole Cannabis Plant works Synergisticly to Provide Medicine

In 1998 Shimon Ben-Shabatt and Raphael Mechoulam coined the term the “Entourage Effect”. This term explains how cannabis medicinally works with terpenes and cannabinoids. They show the importance of all active ingredients of cannabis for maximum effectivness.

The Entourage Effect is directing a new thinking in cannabis medicine. In 1985 Marinol singled out THC as the only active ingredient. Better results have been shown by adding CBD with THC in the medicine Sativex. GW Pharmeceuticals has incorporated the Entourage Effect in their further research to make new cannabis medicine.

The cannabinoids and terpenes in cannabis work together to maximize treatments. Raphael Mechoulam said while introducing the Entourage Effect, “Very seldom is the biological activity of the active constituent assayed together with inactive 'entourage' compounds.” The variety of terpene and cannabinoids profiles create the distinctive effects and strains of the cannabis plant.


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