TRPV1 also known as Type 1
Vanilloid Receptor, Capsaicin Receptor and transient receptor
potential cation channel subfamily V member1 is a protein that the
TRPV1 gene encodes. This receptor regulates body temperature and the
sensation of heat and pain. Found in the nervous system it is a
communicator of pain to the brain, and desensitizing gives a
analgesic pain free feeling.
Cannabinoids found in
marijuana have been found to be an antagonist to the TRPV1 receptor,
which can help with neurpathic pain, multiple sclerosis,
chemotherapy, amputation as well as osteoarthritis, anxiety and long
term depression.(Source)
Cannabidiol CBD has shown to have an activation of the TRPV1
receptors. (Source)
Endocannabinoid anandamide that is affected by the use of cannabis
has been shown to act on the TRPV1 receptors as well. (Source)
Dopamine which is increased with cannabis use also effects the TRPV1
receptor.(Source)
Along with treatment
in symptoms, cannabis can reduce cancer to it's role in the TRPV1
receptor. Neuroblastoma is a cancer started in the nervous system in
the human fetus or embryo that resides in the nervous system. This
form of cancer is usually seen in young children before the age of
10. Research has shown that cannabis can delay or stop the cancer
cell growth of neuroblastoma by activating the TRPV1 receptors.
(Source)
Source:
http://www.ncbi.nlm.nih.gov/pubmed/17442052
