The Benefits of the Terepene Isopulegol in Cannabis

Isopulegol in Cannabis gives a minty odor and flavor. Found in eucalyptus it is a chemical compound formed from cintronellal to make a monoterpene. It's menthol properties gives a soothing taste and sensation that is calming.

Health benefits are minimal as it is usually found in low concentrations. The menthol scent can overpower the other medicinal properties.(Source) Isopulegol along with other menthol oils have shown to give a cooling effect, be anti-inflammatory, an emollient, aid in breathing and ease from aches and pains. It has the ability to target the nerve receptor TRPV1 to extend sensory feelings.(Source)

Research shows promising benefits with isopulegol for the gastrointestinal tract as well as reducing seizures. Ulcers were found to be improved by prostaglandins, K(ATP) channel openings and antioxidant properties.(Source) Seizures were found to be reduced for isopulegols ability to affect the GABA system and it's antioxidants.(Source)

Source:

https://www.icmag.com/ic/showthread.php?t=295057

http://www.britannica.com/EBchecked/topic/296517/isopulegol

http://www.poseidonsciences.com/anti-inflammatory.html

http://planetofhealth.eu/uimage/product/MedicalSudiesOil77.pdf

http://www.google.com/patents/US6267974

http://www.ncbi.nlm.nih.gov/pubmed/19479241

www.ncbi.nlm.nih.gov/pubmed/19559770

Cannabis and the Type 1 Vanilloid Receptor

TRPV1 also known as Type 1 Vanilloid Receptor, Capsaicin Receptor and transient receptor potential cation channel subfamily V member1 is a protein that the TRPV1 gene encodes. This receptor regulates body temperature and the sensation of heat and pain. Found in the nervous system it is a communicator of pain to the brain, and desensitizing gives a analgesic pain free feeling.

Cannabinoids found in marijuana have been found to be an antagonist to the TRPV1 receptor, which can help with neurpathic pain, multiple sclerosis, chemotherapy, amputation as well as osteoarthritis, anxiety and long term depression.(Source) Cannabidiol CBD has shown to have an activation of the TRPV1 receptors. (Source) Endocannabinoid anandamide that is affected by the use of cannabis has been shown to act on the TRPV1 receptors as well. (Source) Dopamine which is increased with cannabis use also effects the TRPV1 receptor.(Source)

Along with treatment in symptoms, cannabis can reduce cancer to it's role in the TRPV1 receptor. Neuroblastoma is a cancer started in the nervous system in the human fetus or embryo that resides in the nervous system. This form of cancer is usually seen in young children before the age of 10. Research has shown that cannabis can delay or stop the cancer cell growth of neuroblastoma by activating the TRPV1 receptors. (Source)

Source:

http://jpet.aspetjournals.org/content/318/3/1375

http://en.wikipedia.org/wiki/TRPV1

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC123079/

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1574087/

http://www.ncbi.nlm.nih.gov/pubmed/17442052