Wednesday, November 5, 2014

How Marijuana Effects GABA in the Nervous System


In short, GABA is a neurotransmitter in the mammal central nervous system that can repress excitability in the neurons in the nervous system and regulation in muscle tone. GABA is an abbreviation for gamma-Aminobutyric Acid which is an amino acid, which are secondary to water to being the biggest component in cells, tissue and muscle that are critical to biosynthesis and being a neurotransmitter. Cannabis plays a crucial role with the endocannabinoid system in suppressing the GABA, aiding in increasing dopamine levels which can help in treatments with medical marijuana.



GABA acts differently in stages of life, playing a roll in the developing brain as an excitatory component in the brain, while in adulthood acting as an inhibition in the brain. GABA regulates embryonic and neural stem cell growth. GABA has been found in the intestine, stomach, pancreas, fallopian tubes, uterus, ovaries, testis, kidney, bladder, lung, liver, lungs, melatonin and eye lens.(Source)

GABA makes up 40% of nerve cells, where glutamate makes up 30%. Glutamate offers excitability to the nervous system and also the brain synthesizes glutamate into GABA, which regulates the excitability, causing a check and balance, or ying and yang effect of controlling the functions. GABA inhibits nerve cells from growing, aggressive behavior, and regulates hyperactivity. (Source)

How Marijuana Inhibits GABA

Marijuana use effects the neurotransmitter GABA by blocking it. The result is increasing dopamine levels which normally GABA inhibits or regulates. Dopamine offers a mood shift of reward for the brain that is released with sex, exercise, appetite, learning, sleep, movement and mood.(Source)

Cannabis effects the cannabinoid receptors, namely Cb1 and Cb2 that mimic a naturally created endogenous molecule, anadamide. Anadamide is an Omega 6 fatty acid that regulates appetite, cognition, emotion, memory, mood and pain. Delta-9-tetrahydrocannabinol (THC) and other Cannabinoids found in marijuana can effect anadamide and therefore effect the endocannabinoid central nervous system.

THC, for instance, binds to the CB1 receptors, which reduces the enzyme cAMP which results in less protein kinase A. This results in potassium and calcium channels that ends up reducing the amount of neurotransmitters being released. This chemical reaction is the result of reducing GABA. A reduction in GABA results in an increase in dopamine. Dopamine do not effect the CB1 receptors. (Source)

Treatments From Inhibiting GABA

Research is still needed for more conclusive results, but promising studies and theories show that cannabis can be an effective treatment for it's ability to effect GABA including:

Tinnitus – A brain induced ringing in the ear.
Fibromyalgia – Tenderness in joints, muscles and other soft tissues.
Anxiety – Stress inducing fear, unease and worry.
Addiction – The difficulty to stop using substances.
Schizophrenia – Difficulty knowing what is real and not, thinking clearly to have normal responses.

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