Thursday, November 6, 2014

The Benefits of Cannabis for Epilepsy


Cannabis with a high content of Cannabidiol CBD have been found to help treat epilepsy in some patients. A certain type of epilepsy, called Dravet Syndrome has shown the most promising treatment with marijuana than other types of epilepsy. Most treatment is administered with a cannabis oil from the Charlotte's Web Strain made by a non-profit organization Realm of Caring(Source), however much of the CBD rich cannabis administered gives similar treatment and different concentrations of CBD, THC and THCA are needed for a more precise treatment for the patient. Legislation and regulation of the medicine is targeting a CBD only medicine, but many believe it is the whole plant that offer the effects, not just the CBD cannabinoid.(Source)

Here is a compiled list of studies that show the benefits of Cannabis with Epilepsy:

September 2003 - The Journal of Pharmacology and Experimental Therapeutics - The Endogenous Cannabinoid System Regulates Seizure Frequency and Duration in a Model of Temporal Lobe Epilepsy
This study showed in rats that had epileptic seizures to be reduces or terminated with THC and CBD from the effect that the cannabinoids had on the CB1 Receptors.

March 2004 – US National Library of Medicine - Endocannabinoid Effects on Febrile Seizures: Not Just a Toke(n) Mechanism
This study showed that in rats a febrile seizure lasting up to 22 minutes was regulated or terminated with cannabis from it's ability to inhibit GABA, a form of neurotransmitters, which also shows that the result of seizures relies in the increase of GABA being released.

May 2004 – US National Library of Medicine - Cannabinoids: Defending the Epileptic Brain
Another study showing the benefits of Cannabis affecting mice in the CB1 receptors, using both the THC and CBD.

June 2004 – Neurology.org - Marijuana use and epilepsy
This is a telephone survey, calling people with epilepsy and finding if they have used marijuana treatment and their findings. 24% of patients called felt that marijuana was an effective treatment for their epilepsy.

November 2004 – ScienceDirect.com - On-demand activation of the endocannabinoid system in the control of neuronal excitability and epileptiform seizures
This study formulates a theory that certain types of seizures can be surpressed or increased with the cannabinoid system and how it regulates the GABA can help regulate the endocannabinoid system.

January 2006 – US National Library of Medicine - Endocannabinoids: A Critical Regulator of Activity in the Developing Brain
 Study showing that the theory that during pregnancy the interferance with marijuana to inhibit CB1 activity or an obesity drug that increases CB1 activity can disrupt the developing endocannabinoid system.

Marijuana and Epilepsy – page on Neuro Science Fundamentals This article talks about Charlotte Figi's story and the introduction of the Charlotte's Web strain to help treat epilepsy.
Edward Maa M.D, an assistant professor at the University of Colorado Department of Neurology,is conducting a study at University of Colorado Anshutz Medical Campus on epilepsy research. The study will separate epilepsy sufferers in two groups of whether the Charlotte's Web strain reduces the epilepsy symptoms by 50% and another group that the symptoms are not helped by the cannabis strain. He will do genetic analysis to find out what the differences in the epilepsy is to help target the marijuana to the correct patients.(Source)

On July 28th, 2014 The Realm of Caring released the Charlotte's Web Medical Hemp Act of 2014 to legalize federally the CBD only oil for epilepsy. Many believe this is not a complete effort for treatment, Edward Maa is at the forefront in writing articles on how important it is for the treatment to use the whole plant, just not the isolated Cannabidiol CBD.(Source) Jason David, a parent treating his 7 year old son with epilepsy mentions in a report by ladybud.com that his son Jayden suffered from the wrong concentration of cannabinoids from the Charlotte's Web strain. He states:

“They’re not telling the whole truth,” says David. “There’s no way possible that all these children in Colorado could get seizure control and get off all their medications without using different ratios and adding THC and THCA (which are not allowed by the newly proposed legislation). Charlotte’s Web can work great in the beginning but it’s impossible to get off all the medications and go through benzo withdrawals without being able to play with the THC ratios.” (Source)

 
Source: http://time.com/3264691/medical-marijauna-epilepsy-research-charlottes-web-study/ http://onlinelibrary.wiley.com/doi/10.1111/epi.12610/abstract http://www.ladybud.com/2014/07/29/a-limited-amount-of-caring-parents-and-advocates-react-to-realm-of-carings-federal-cbd-only-bill/ http://theroc.us/index.php?option=com_k2&view=item&id=22:charlotte-s-web-medical-hemp-act-of-2014&Itemid=498

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