How Cannabis Increasing Ceramide Helps Cancer Patients

A ceramide is a waxy lipid molecule found in cell membranes. It is found throughout the body, especially on the outer layer of skin. Ceramides help with cell differentiation, proliferation, and also aid in cell death. Marijuana, which increases ceramide, can be used to reduce cancer tumors.(Source)

Cannabis has been found to increase the messenger molecule anandamide, which induces the creation of ceramide. Using topical creams and ingesting marijuana has been shown to increase ceramide levels in the cells. Research has shown that an increase in ceramide allows cells with mitochondrial dysfunction or dysregulation to die. (Source) The ceramide disrupts the mitrochondria which releases cytochrome c and reactive oxygen into the cytosol, leading to cell death. The ceramide increase does not cause an apoptosis reaction in normal, healthy cells.(Source)

Our skin (or epidermis) has the highest concentration of ceramide. It maintains a barrier for the skin which slows environmental damage and retains moisture. Ceramide levels in the skin drop as we age. Signs of low ceramide include dry skin, wrinkles, and eczema.

Source:

http://www.cureyourowncancer.org/how-cannabis-oil-works.html

http://en.wikipedia.org/wiki/Ceramide

http://www.ncbi.nlm.nih.gov/pubmed/15958274

http://www.nature.com/nm/journal/v6/n3/full/nm0300_313.html

https://patients4medicalmarijuana.wordpress.com/how-cannabinoids-kill-cancer-dennis-hill/

http://www.ncbi.nlm.nih.gov/pubmed/19228959

The Cannabis Terpene Alpha Pinene

Alpha Pinene is the most common terpene in the plant world and also found in cannabis. Other plants such as basil, dill, parsley, pine needles, and rosemary are rich in α-pinene . Some of the cannabis strains that offer the most alpha pinene terpene are Bubba Kush, Chemdawg, Jack Herer, Super Silver Haze and Trainwreck.

Terepenes offer medicinal effects when consumed or used topically. Terepenes have shown to help in the biosynthesis for CB2 receptors in the endocannabinoid system.(Source) Alpha pinene works synergistically with THC to help regulate the psychosis effects when consuming cannabis.(Source) Alpha pinene is an organic compound offering medicinal value for many applications.

Alpha pinene has shown to give anti-inflammatory properties(Source). This allows for uses in arthritis, celiac disease, crohn's disease, joint pain and multiple sclerosis where a reduction in inflammation can aid in pain relief. Memory retention is increased with alpha pinene for it's ability to inhibit acetylcholinesterase activity in the brain.(Source)

Currently research is being conducted to show the benefits of alpha pinene slowing cancer tumor growth. A 2013 study showed how cancer cells were reduced with pinene on neurblastoma cells.(Source) A 2014 study using an anti-tumor drug concluded that pinene mitigated hepatoma carcinoma.(Source)

Many patients seek cannabis strains high in alpha pinene for it's benefits in asthma treatment and infections. Pinene has shown to be a bronchodilator. It helps to open the airways of the upper respiratory system.(Source) Pinene also has been found to be anti-microbial with the ability to treat bacteria as well as virus infections. Certain bacteria infections have shown positive results with pinene. Pinene has also been found to treat the infectious bronchitis virus. This virus is much harder to treat than bacterial infections.(Source)

Source:

http://theleafonline.com/c/science/2014/10/terpene-profile-pinene/

http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2011.01238.x/abstract

http://www.revistas.usp.br/rbcf/article/viewFile/44190/47811

http://www.ncbi.nlm.nih.gov/pubmed/15740071

http://link.springer.com/article/10.2478%2Fs11756-013-0230-2#page-1

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165946/

http://www.ncbi.nlm.nih.gov/pubmed/24815485

http://www.ncbi.nlm.nih.gov/pubmed/12122569

http://www.ncbi.nlm.nih.gov/pubmed/21350392

Beta Myrcene is the Most Common Terpene in Cannabis

Beta Myrcene is the most common terpene found in cannabis. It has a spicy herbal scent that is known to aid in treatment to pain, inflammation and muscle relaxation. This terepene is also found in bay leaves, eucalyptus, hops, lemongrass, mangos, parsley and thyme. The high amount of β-Myrcene in Indica strains are what give the “couch-lock” sedative effect.(Source)

Myrcene, or β-myrcene is a monoterpene which is a volatile compound that evaporates quickly with exposure to air. It is known as an essential oil for its fragrance and is used for menthol and citronella products. Cannabis strains that contain high amounts of Beta Myrcene are White Widow and Neville's Haze.(Source)

The benefits of Beta Myrcene are found in it's analgesic, anti-tumor, anti-inflammatory, sedative and ability to reduce muscle spasms. Lemon grass tea is known for it's pain relieving effects due to it's high content in β-myrcene. Studies with high content of Myrcene in mice have shown a sedative quality. The terpene has a unique ability to intesify the effects of the CB1 receptors in the body which helps in inflammation and pain relief.

Myrcene lowers the resisistance across the blood brain barrier. This effect makes other chemicals like THC to absorb and take effect more quickly. Indica strains in cannabis offer a .5% or greater potency in myrcene allowing for better delivery of THC and it's effects. Sativa strains typically contain less than .5% which allows the effects to be more subtle. It has been found that eating a mango a half hour before smoking cannabis increases the psycho active effects for it's high content of β-Myrcene.

Source:

http://pubchem.ncbi.nlm.nih.gov/compound/31253?from=summary

http://en.wikipedia.org/wiki/Myrcene

http://steephilllab.com/resources/cannabinoid-and-terpenoid-reference-guide/

http://www.ncbi.nlm.nih.gov/pubmed/24956819

http://www.marqaha.com/#!under-microscope/c1cbz

Pediatricians Urge the Government to Accept Cannabis Medication

In 2015 pediatricians started out with positive pressure to reclassify marijuana. The American Academy of Pediatrics urged the U.S. Drug Enforcement Agency for more research into the benefits of cannabis medication. They also called for compassion for their patients to use marijuana.

Doctors and parents have seen beneficial uses of cannabis for children. Cannabis rich in the cannabinoid CBD has shown to reduce epileptic seizures in children with dravet syndrome. Some cases have shown that CBD has also reduced brain tumors in children. Cannabis use has also shown to help with autism in verbal communication and reducing self injury.(Source)

Currently the government has taken steps to legitimize it as a beneficial drug. The government holds a patent for the beneficial use of cannabis. Prescribed cannabis medication like Dronabinol and Sativex are out on the mainstream market for treatment in nausea, neuropathic pain, spasticity and overactive bladder. The U.S. Governement owns a marijuana farm at the University of Mississippi for research.

The AAP wants to specifically change the way cannabis is classified as a schedule 1 drug. This current classification restricts marijuana from research and use as a medication to the public.

Source:

http://www.wsj.com/articles/BL-270B-1364?utm_content=bufferdcc0e&utm_medium=social&utm_source=twitter.com&utm_campaign=buffer

https://faceofcannabis.wordpress.com/2013/10/24/calvin/

The Benefits of Cannabichromene (CBC)

     

Cannabichromene CBC Creates Brain Stem Cells

  Cannabichromene (CBC) is a cannabinoid in marijuana that is in low concentration but high in healing properties. Research has shown that CBC helps in pain, depression, inflammation, bone growth, increase brain cells and reducing cancerous tumors. More research is needed but many scientists believe that CBC in conjunction with the other cannabinoids work together as a whole to provide the best medicinal effects.

   Cannabigerolic Acid (CBCA) is the initial cannabinoid form that the raw cannabis plant starts with. With age and oxidation this quickly breaks down with enzymes into CBDa, THCa and CBCa. The CBCa form when heated will lose a CO2 molecule allowing it to convert to Cannabichromene (CBC).

   CBC effects with the brain are exciting and promising for modern medicine to help with Alzheimer's and dementia. An Italian study found that CBC promotes brain cell growth with adult neural stem cells. Studies have shown that adults brain cell growth slows and the decline can lead to memory loss. Though the studies are with mice so far, the study done by GW Pharmaceuticals gives hope for a treatment for degenerative brain diseases.(Source) 
 

   CBC has also shown to reduce cancer cells and shrink tumors along with the cannabinoids CBD and CBG. They allow anandamide to inhibit cancer cell growth. Cannabidiol (CBD) shows the highest potency with CBC and CBG being next in potency. Allowing all cannabinoids to work synergistic-ally allows them to target different receptors to inhibit cancer growth. (Source)

Other great benefits include:

• Bacteria like Staph and E.Coli showed inhibited by CBC. (Source)
• CBC has been found in studies to be an anti-inflammatory in mice. (Source)
• CBC targeting the nervous system to control pain at a chronic level.(Source)
• Euphoric uplifting properties are given with CBC that works differently than THC. (Source)
• CBC acts as a bone-stimulant (Source)

Source:

http://www.medicaljane.com/2013/08/14/cannabichromene-cbc-is-the-most-disregarded-cannabinoid/
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3417459/
http://www.sciencedirect.com/science/article/pii/S0197018613002106
http://montanabiotech.com/2011/09/20/breast-cancer-antitumor-effects-inhibition-of-cancer-cell-proliferation-and-treatment-using-medical-cannabis-marijuana-derived-cannabinoids-tetrahydrocannabinol-cannabidiol-cannabigerol-cannabichromen/
http://www.ncbi.nlm.nih.gov/pubmed/20942863

http://www.delta9.ca/resources/Cannabinoids%20-%20General/Cannabinoids%20Primer%20New.pdf

The Benefits of Cannabigerol (CBG)

  Cannabigerol CBG is a cannabinoid in marijuana that has medicinal properties. Found in low concentrations in many strains of cannabis it is often overlooked. CBG works in conjunction with THC to tone down the paranoia feeling.(Source) Alone it aids in treatment to depression, tumors, inflammatory bowel disease, glaucoma, bacteria infections, high blood pressure, reduce blood clotting, anxiety and muscle tension.

   Research has proven many treatments from Cannabigerol. Here is a list of the numerous benefits of CBG:

Depression: GW Pharma has a patent for the use of Cannabigerol CBG to treat clinical depression.(Source)

Cancer \Tumors: New research this year has shown that CBG reduces cancer cells and tumors in the colon.(Source)

Inflammatory Bowel Disease: CBG reduced inflammation and over-production of nitric oxide which can lead to sustained IBD.(Source)

Glaucoma: CBG shows promising treatment for glaucoma by relieving ocular pressure. More importantly CBG showed 2-3 times the benefit of eye drainage than other medicines.(Source)

Bacterial Infections: Bacterial infections have been treated including MRSA.(Source)

Reduce Heart Rate and Blood Clotting: Has shown as a proven treatment for the way it reduces platelet aggregation.(Source)

Anxiety and Muscle Tension: CBG is able to treate with it's ability to inhibit GABA production.(Source)

Cannabis initially starts with creating cannabinoid cannabigerolic acid (CBGa). This is typically broken down with exposure to air and UV light into THCa, CBDa or CBCa. If it remains as CBGa, then it will convert to CBG when heated. Some industrial strains retain the CBGa with as much as a 94% concentration. It is thought this strain has a recessive gene that doesn't allow the conversion to the THCa, CBDa or CBCa. Currently some growers are using this knowledge to create strains rich in CBG like the Mickey Kush Strain.

Source:

http://www.medicaljane.com/2013/08/03/cannabigerol-cbg-is-a-minor-cannabinoid-with-major-impact/

http://www.ncbi.nlm.nih.gov/pubmed/25269802

http://www.sciencedirect.com/science/article/pii/S0006295213000543

http://www.google.com/patents/CA2655094C?cl=en

http://www.amazon.com/Cannabis-Therapeutics-HIV-AIDS-Journal/dp/0789016990/ref=sr_1_1?s=books&ie=UTF8&qid=1418758497&sr=1-1&keywords=9780789016997

http://onlinelibrary.wiley.com/doi/10.1111/j.2042-7158.1989.tb06345.x/abstract

Essential Fatty Acids in Cannabis

Cannabis in the form of hemp seeds holds forty-four percent of it's weight in edible oils.  These oils comprise eighty percent of essential fatty acids (EFAs) which include Linoleic Acid (55%), Alpha-Linolenic Acid - Omega-3 (22%), Gamma-Linolenic Acid - Omega-6 (1-4%) and Stearidonic Acid - Omega -3 (0-2%)(Source). Cannabis derived from flowers has been found to include many fatty acids including palmitic, myristic, oleic and stearic acids. (Source)

Omega 3 Fatty Acids in plant form have been found to help with arthritis, depression, infant development, asthma, ADHD, Alzheimer's and Dementia. These acids have been shown to act primarily as an anti-inflammatory agent.(Source) Studies have also shown that an increased diet including Omega 3 fatty acids helps to reduce ADHD symptoms.

Omega 6 fatty acids, also known as polyunsaturated fatty acids (PUFAs), have been shown to help with brain function, growth and development, skin and hair growth, metabolism regulation, bone health and the functions of the reproductive system. (Source) A diet with higher levels of Omega 3's vs. Omega 6 has been shown to be healthiest overall. However Omega 6 acids have been found to help with specific health  problems which may not be addressed solely through a diet including use of Omega 6 acids. Linolenic Acid (GLA) has been shown to help with nerve pain in people with diabetic neuropathy or arthritis. Studies have shown more allergies in woman with low GLA in breast milk or blood. GLA has been shown to help with a breast cancer drug tamoxifen and help inhibit tumor activity. (Source)

Cannabis is a nutritious food source that offers essential fatty acids, all 9 essential amino acids and 65% of globulin edistin.

Source:

http://en.wikipedia.org/wiki/Hemp

http://www.webmd.com/healthy-aging/omega-3-fatty-acids-fact-sheet

http://umm.edu/health/medical/altmed/supplement/omega6-fatty-acids

http://forendex.southernforensic.org/uploads/references/MicrogramJournal/5.1-4.20.25.pdf

Different Cancers that Have Been Shown to be Reduced with Cannabis

Tumors in the brain have shown promising results to reduce or be destroyed through many research studies using marijuana. The inhibiting of cancer cells to proliferate do not stop with tumors in the brain. Studies have shows that there are promising results for many other cancer cells. Here is a list and studies on how cannabis-based medicine.

• Biliary Tract Cancer (cholangiocarcinoma)(Source)
• Breast Carcinoma – By inhibiting anandamide(Source)
• Cervical Carcinoma – By increase of inhibiting tissue of Matrix Metalloproteinases-1 (MMP-1)
(Source)
• Colorectal Carcinoma - Cyclooxygenase 2 (COX-2) found in most colorectal cancer cells were reduced by the increase in anandamide, which increases with cannabis use.(Source)
• Leukemia Cells – THC induces Leukemia cell death. (Source)
• Lymphoma – used with other drugs to induce lymphoma cell death (Source)
• Lung Carcinoma – THC induced Lung Cancer cell death. (Source)
• Neuroblastoma – Type 1 Vanilloid Receptor (Source)
• Oral Cancer – By inhibiting O(2) in Oral Cancer cells to cause death to cells (Source)
• Pancreatic Adenocarcinoma – By increasing ceramides and affecting the CB2 receptors (Source)
• Prostate Carcinoma – By increasing ceramides and effects on anandamide (Source)
• Skin Carcinoma – By activating the CB1 and CB2 receptors (Source)
• Thyroid Epithelioma – CB1 Receptors (Source)

• Uterus Carcinoma - Cell Growth Inhibition (Source)

Cannabis Reduces Brain Tumors

Cannabinoids found in marijuana have shown to inhibit tumor cell growth. This is achieved in how they effect signaling pathways in the brain. Treatment with cannabis has been found to be cheaper to produce and have less side effects and toxicity to other conventional chemo therapies and drugs, encouraging further research to make it a mainstream medicine.(Source)

In 1998 it was first recorded that delta-9-THC promoted cell death in glioma (brain tumor) cells in cultures.(Source) In 2000 a study was done with THC as well as WIN 55,212-2 which is a chemical that shows effects similar to cannabinoids, with a completley different chemical structure. Both increased ceramides which inhibited cancer cell growth.(Source) Ceramides are fatty acids that tumor cells seem to invite in. Ceramides communicate with the lysosomes in the cells to tell them to burst, killing the cancer cell. Ceramides are also important in hair and skin acting as a protective shield against the environment.(Source)

A study in 2003 found that THC in laboratory tests create cell destruction in cells by modifying the signal pathways inside the tumor, allowing it to disrupt growth or kill the tumor. (Source) With much discussion about THC benefiting tumor cell death, research also concluded that the cannabinoid CBD also showed equally promising results in tumor cell death without the psycho active properties. (Source)

In 2004 it was found that cannabinoids reduce tumor growth by affecting the vascular endothelial growth factor, VEGF, or the function of giving blood supply to tissue when circulation is inadequate. The blocking of the pathway to blood flow of tumors showed a reduction in the tumor cells. (Source)

In 2005 a study found that THC did a better job of only inhibiting the growth of tumor cells as opposed to healthy cells more effectively than the chemical medicine WIN 55,212-2. (Source)

Professor Guzman who conducted a lot of these research studies found in 2006 that patients with reoccuring glioblastoma multiforme showed a reduction in tumors. (Source) In 2010 it was found in research that a widely used chemotherapy drug used to treat brain tumors called temozolomide (TMZ) increased effectiveness when administered with THC. (Source) A report was published in 2011 in which two children using cannabis to treat cerebellar and optic pathway tumors by inhibiting the growth effectively.(Source)

In 2014 glioma, an aggressive and hard to treat cancer in the brain was treated with CBD and THC along with radiotherapy. Results found that the combination of the cannabinoids found in marijuana improved the radiotherapy by prepping the glioma cells to receive the ionizing radiation more effectively and reducing the tumor cells.(Source)

Source:

http://www.nature.com/nrc/journal/v3/n10/abs/nrc1188.html

http://mct.aacrjournals.org/content/early/2014/11/12/1535-7163.MCT-14-0402.abstract

http://norml.org/library/item/gliomascancer

http://molpharm.aspetjournals.org/content/54/5/834.short

http://www.sharecare.com/health/cancer-treatment/how-ceramides-help-fight-cancer

http://jpet.aspetjournals.org/content/308/3/838.full

http://mct.aacrjournals.org/content/10/1/90.abstract

http://www.ncbi.nlm.nih.gov/pubmed/21336992

The Benefits of Cannabidiol (CBD)

Cannabidiol CBD

Cannabis strains offer different amounts of Cannabidiol (CBD) doesn't affect the mind or psycho activity which is caused by the Tetrahydrocannabinol ( THC ) in cannabis. Cannabidiol has the widest use for medical applications than any other form of cannabis. As a strong antioxidant being the major reason for it's benefits, Cannabidiol CBD has been used in studies to research treatment and cures.


Some of the medical applications are a US drug known as Epidiolex to treat the Dravet Syndrome, a type of Epilepsy starting at about 6 months of age that triggers seizures from fever or hot temperatures. It also helps with blood flow to extremeties, or anti- ischemic problems, which effect many people notably diabetics. Great results have been found with schizophrenia and seizures in it's ability to disrupt or stabilize the NMDA receptors in the brain which can over excite and kill nerve cells.


An 8 month old baby showed to have an inoperable brain tumor and the parents were desperate for a cure, open to any method. Under Dr. William Courtney's care the father gave a pacifier to the baby with Cannabinoid Oil CBD on the pacifier twice daily, increasing the dosage. The first two months showed the greatest improvement, with the tumor gone by 8 months.


Tumors have shown through studies to be reduced with Cannabidiol CBD. Studies have shown that Cannabidiol disrupt and halt the genes that lead to blood vessel growth in tumors by producing a chemical called Vascular Endothelial Growth Factor, or VEGF. What happens is that Cannabidiol produce ceramides, and ceramides manage the cell death.


Cannabidiol CBD applied topically has been shown to stop the MRSA Virus that is hard to stop through normal anti-biotics.


Cannabidiol CBD is also an anti-depressant. It can aid in controlling anxiety, which helps with social situations and isolation problems. It helps reduce the activity of the limbic system, a part of the brain that deals with emotion.


Animal studies show favorable results with help for Parkinson Disease, however human studies are inconclusive. Problems found with Cannabidiol is that if taken orally it triggers the sebum, the gland that makes oil in the skin to overproduce leading to acne.

OUTCO is San Diego's only legally licensed medical marijuana dispensary offering FREE Delivery and Accepting Debit Cards.


Sources:
http://preventdisease.com/news/13/050313_There-Is-No-Mistaking-The-Evidence-Cannabis-Cures-Cancer.shtml
http://en.wikipedia.org/wiki/Cannabidiol
http://www.lifeadvancer.com/cannabis-oil-cures-8-month-old-infant-of-cancer-dissolving-large-inoperable-tumor-in-8-months