Cannabis Effecting Obesity and Type 2 Diabetes

The case of the “Munchies” would lead one to think that it leads to obesity, but in fact on average it reduces obesity by one third.(Source) Though the caloric intake may be more caused with the munchies, cannabis reacts with the metabolization of carbohydrates and regulation of insulin to reduce obesity and type 2 diabetes.

"The most important finding is that current users of marijuana appeared to have better carbohydrate metabolism than nonusers," says Murray Mittleman, associate professor of medicine at Harvard Medical School. "Their fasting insulin levels were lower, and they appeared to be less resistant to the insulin produced by their body to maintain a normal blood-sugar level."

Fasting insulin levels from the study were sixteen percent lower and 17% lower in insulin resistance. These two factors are increased with type II diabetes. (Source)

Research has yet to understand why this is occurring and some theories that haven't been proven have been offered:

• Marijuana is a replacement for food for some users
• Other active parts of the cannabis plant like cannabidiol may interact with the brain receptors to help manage the metabolism and regulate eating.
• Regular use of cannabis may dull the receptors and have them not react too strong to wanting to increase appetite over time.

One drug that has been taken off the market because of the side effects of causing increased suicide may offer an answer to the reason why the appetite is controlled through cannabis. The drug Rimonabant used as a weight loss drug targeted the same brain receptor (CB1) that cannabis does. It's effect made a lower drop in fasting insulin levels by lowering the receptors signaling. (Source)

Source:

http://aje.oxfordjournals.org/content/early/2011/08/24/aje.kwr200.abstract?__hstc=9292970.2e518383c30fe9090ca33584378a6435.1409929942141.1411273921013.1411401471685.9&__hssc=9292970.1.1411401471685&__hsfp=210472818

http://www.amjmed.com/article/S0002-9343%2813%2900200-3/abstract

http://www.cnn.com/2013/05/23/health/time-marijuana-diabetes/index.html?__hstc=9292970.2e518383c30fe9090ca33584378a6435.1409929942141.1411273921013.1411401471685.9&__hssc=9292970.1.1411401471685&__hsfp=210472818

The Reason Behind Cannabis and the Munchies

For chemotherapy patients struggling to increase their appetite, marijuana can increase their desire to eat being beneficial. Tetrahydrocannabinol or THC which is the psychoactive part of cannabis has been found to be the factor to increasing appetite. There are a couple studies that show different reasons on why marijuana increases the “munchies”, and it may be a combination of the various factors.

Two studies showed that an increase in hedonic, or pleasurable taste, rather than a motivation to eat was increased with the use of cannabis. With exposure to taste and scent, dopamine is released with encourages the appetite for the food. Once THC is in the blood stream, it has been found to increase dopamine levels.(Source) and (Source)

In a study published in Proceedings of the National Academy of Sciences a research group led by Daniele Piomelli found that marijuana triggers the CB1 receptors in the gut, not the brain, to signal that a fatty food has been ingested. The saying of “You just can't eat one Lay Potato Chip” is correct in that when a fatty food is eaten, intestinal CB1 receptors send a message to the brain to stimulate the creation of endocannabinoids creating a chemical response of hunger increasing your appetite for fatty foods. (Source)

Another study shows how endocannabinoids are responsible for pre and post natal survival. Endocannabinoids are present in cow's milk, soft cheese and breast milk. The research showed that the cannabinoid receptors are stimulated by the cannabinoids in milk to encourage suckling leading to newborn survival. This response may hold a connection in later life to the encouragement of eating.(Source)

Another study showed the THC released the hormone ghrelin, which increases appetite. Both endocabbinoids and ghrelin effect the hypothalamus part of the brain. AMP-activated protein kinase, or AMPK helps regulate cell energy metabolism. THC and ghrelin increase appetite by stimulating the AMPK to allow the hypothalamus sense of food deprivation thereby increasing hunger.(Source)

Recently in February 2014 a study was published in Nature Neuroscience studied the increase in smell with cannabis. The study used the underlying basis that hunger leads to an increase in sensory perception which leads to an increase in food intake. The results in the study with mice showed that odor detection was increased with cannabis due to CB1 receptors affecting the olfactory bulb enhancing the sense of smell. This increased awareness to smell gives in turn the increase to hunger. The mice stayed longer smelling the food and ate more.(Source)

Cannabis and Obesity

Though the study finding show that caloric intake from marijuana goes up with the urge to eat, another study two studies show that marijuana users are one third less likely to be obese and have a lower rate of Type 2 Diabetes.(Source) Read more on this by clicking this link.

Source:

http://www.nature.com/neuro/journal/v17/n3/full/nn.3647.html

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705914/

http://www.ncbi.nlm.nih.gov/pubmed/16185725

http://www.jbc.org/content/280/26/25196.full

http://www.pnas.org/content/108/31/12904

http://www.sciencedirect.com/science/article/pii/S0014299904007423

http://aje.oxfordjournals.org/content/early/2011/08/24/aje.kwr200.abstract?__hstc=9292970.2e518383c30fe9090ca33584378a6435.1409929942141.1411273921013.1411401471685.9&__hssc=9292970.1.1411401471685&__hsfp=210472818