2-Arachidonoylglycerol
(2-AG) is the most abundant endocannaboinoid messenger molecule that
effects the
TRPV1, CB1
and CB2 receptor. 2-AG
is 170 times the concentration of anandamide which also effects the
same receptors. 2-AG is naturally
created in humans and also found in human and cattle milk. (Source)
So
why does this matter? Because 2-AG and anandamide is created
on-demand naturally by the body, and an imbalance to the body to
produce too much or little is thought to lead to disorders.
Drug therapies that target the CB1, CB2 receptors bring the
body back to a balance where 2-AG is lacking.(Source)
It is theorized that diseases such as bipolar(Source)
and alzheimer's(Source)
could occur from an imbalance of 2-AG being created in the body.
The nerve cells affected by
2-AG control body temperature, appetite, memory, mood, inflammation,
immunity and the sensation of heat and pain. Studies
show that it may inhibit cancer cell formation.
2-AG is created from 20-carbon essential
fatty acids (EFA). Cannabis is a good source of EFA's that mimics
2-AG functions.(Source)
Cannabis drug therapies have
been developed to treat symptoms of many problems by mimicking the
2-AG messenger molecule. Some examples of treatment are for memory,
pain, nausea, wasting syndrome, cancer, spasticity from multiple
sclerosis and tremors from Parkinson's disease.
2-AG plays an important role
in traumatic brain injuries. When
a brain injury occurs 2-AG has been found to be elevated.
A study with mice was done where they gave a drug to boost the levels
of 2-AG after a brain injury. The
results were a quicker recovery, reduced inflammation, swelling and
brain cell death.(Source)
Source:
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