The Benefits of the Terpene Delta 3 Carene

Delta 3 Carene gives a calming feeling to aid in well being. This pine scented terpene can be found in rosemary as well as cannabis. Delta 3 Carene is so prevalent in marijuana that it is found in most strains.

Carene has been used as an antihistamine to help with reducing fluid. Some patients use strains high in Carene to help reduce perspiration or menstrual flow. Many patients can describe certain cannabis strains with a side effect of causing dry mouth or eyes. The terpene Delta 3 Carene is a major culprit to this effect.

Medically Carene can treat symptoms of many diseases. Anti-inflammatory properties have been found with this essential oil to treat joint pain and multiple sclerosis.(Source) Delta 3 Carene has shown to be a sedative by acting as a central nervous system depressant. (Source) This ability to slow down the brain function can help in treating anxiety and insomnia.(Source)

Source:

https://www.icmag.com/ic/showthread.php?t=275717

http://terpenes.weebly.com/

http://europepmc.org/abstract/MED/2772005

http://en.wikipedia.org/wiki/Carene

http://www.drugabuse.gov/publications/research-reports/prescription-drugs/cns-depressants/what-are-cns-depressants

Testimonial - Pill Popping Be Gone

Medical Marijuana Testimonial	After more than a decade on over 20 pills a day (that seemed to get me by) I have tried medical cannabis. This has changed my life. A feeling of happy, clear and calm with only a puff. Just get over the stigma of "doing drugs" and start to feel good!
Strains you Like	Harlequin, Super Lemon Haze, Blue Moon
Conditions	PTSD
Symptoms	Anxiety Depression Pain: Neuropathic

Testimonial - Anxiety

Medical Marijuana Testimonial	I dealt with anxiety for most of my adult life.  Most cannabis made that worse.  After trying  xanax, valium, alcohol, none of them were a palatable solution. Then I bought some ACDC at Outco and found nature's cure to anxiety disorders.  It is a high CBD strain (20:1) and they have others as well.  Also, now that my anxiety is dealt with, I also enjoy the other medicinal benefits of cannabis.  Thanks for making quality medicinal strains available to San Diego County all done within the confines of the law.
Strains you Like	ACDC, Mr. Nice, Skywalker OG, Donna OG, Cannatonic, Harlequin, Harle-Tsu, Jack Herer
Conditions
Symptoms	Anxiety Depression Insomnia

Testimonial - PMDD

Medical Marijuana Testimonial	Just having the ability to acquire medicinal marijuana is worth as much as the relief it brings. My main complaint is pain, and since pain equals weakness, I prefer going to a controlled environment where my meds have been tested. This way I know for a fact what it is that I'm buying, no guess work required. Better yet, there's no middle-man, no stranger on the street, and violence is virtually unheard of among regular users such as myself. Now, if we could just get them tested for pesticides, mold and fungi, AND have Medicare pay for it...
Strains you Like	Ringo's Gift, J-1, Candy Jack, ATF
Conditions	ADD ADHD Bipolar Disorder Migraine PMS
Symptoms	Anxiety Cramps Depression Loss of Appetite Pain: MuscleJoint Pain: Neuropathic
Other	PMDD is what I have, it just hasn't been able to be verified.

The Terpene β-Caryophyllene in Cannabis

The Terpene β-Caryophyllene is the Only Approved Cannabinoid

The terpene caryophyllene gives a spicy peppery scent to some cannabis strains. It is also found in black pepper, cloves, cotton, hops, oregano and rosemary. β-Caryophyllene is a unique terpene categorized as a cannabinoid (BCP). This classification is from the way it effects the CB2 receptor. The relation with the receptor helps with anxiety, perception of pain and depression.(Source) Studies have also shown it to act as a neuroprotectant and reduce alcohol consumption.(Source)

Caryophyllene has been shown to help anxiety, arthritis, autoimmune disorders, inflammation, multiple sclerosis symptoms and gastrointestinal problems. Studies with β-Caryophyllene are promising for how it works as a cannabinoid without any psychotic effects. This is due to how it effects the CB2 receptors without effecting the CB1 receptors which give the marijuana high.(Source)

Strains that are high in caryophyllene include Super Silver Haze, Nevilles Haze and Hash Plant. Marijuana sniffing dogs are trained to look for the smell of Caryophyllene.(Source) Β-Caryophyllene is the first FDA approved cannabinoid.

Source:

http://www.leafscience.com/2014/07/08/b-caryophyllene-terpene-anxiety-depression/

http://www.sciencedirect.com/science/article/pii/S0031938414003400

http://en.wikipedia.org/wiki/Caryophyllene

http://www.sciencedirect.com/science/article/pii/S0091305714001956

CBD Tinctures

CBD Tinctures at OUTCO

OUTCO offers CBD Tinctures at the El Cajon Dispensary or Free Delivery for your convenience. Patients describe Cannabidiol (CBD) as treatment for pain, depression, anxiety, muscle spasms, and inflammation. Clinical research has shown CBD to be anti-bacterial, reduce cancer cells, a bone stimulant and a neuroprotectant. CBD is the cannabinoid in marijuana that has the most known benefits without a psychotic effect.

Typically patients use the tincture by putting 1-3 drops under their tongue. More drops can be used as needed. OUTCO has a proprietary method of extracting the CBD to a high concentrated form. Tinctures come in a choice of glycerin or alcohol. Glycerin patients describe as tasting better, while alcohol seems to provide more immediate relief.

The Benefits of Cannabigerol (CBG)

  Cannabigerol CBG is a cannabinoid in marijuana that has medicinal properties. Found in low concentrations in many strains of cannabis it is often overlooked. CBG works in conjunction with THC to tone down the paranoia feeling.(Source) Alone it aids in treatment to depression, tumors, inflammatory bowel disease, glaucoma, bacteria infections, high blood pressure, reduce blood clotting, anxiety and muscle tension.

   Research has proven many treatments from Cannabigerol. Here is a list of the numerous benefits of CBG:

Depression: GW Pharma has a patent for the use of Cannabigerol CBG to treat clinical depression.(Source)

Cancer \Tumors: New research this year has shown that CBG reduces cancer cells and tumors in the colon.(Source)

Inflammatory Bowel Disease: CBG reduced inflammation and over-production of nitric oxide which can lead to sustained IBD.(Source)

Glaucoma: CBG shows promising treatment for glaucoma by relieving ocular pressure. More importantly CBG showed 2-3 times the benefit of eye drainage than other medicines.(Source)

Bacterial Infections: Bacterial infections have been treated including MRSA.(Source)

Reduce Heart Rate and Blood Clotting: Has shown as a proven treatment for the way it reduces platelet aggregation.(Source)

Anxiety and Muscle Tension: CBG is able to treate with it's ability to inhibit GABA production.(Source)

Cannabis initially starts with creating cannabinoid cannabigerolic acid (CBGa). This is typically broken down with exposure to air and UV light into THCa, CBDa or CBCa. If it remains as CBGa, then it will convert to CBG when heated. Some industrial strains retain the CBGa with as much as a 94% concentration. It is thought this strain has a recessive gene that doesn't allow the conversion to the THCa, CBDa or CBCa. Currently some growers are using this knowledge to create strains rich in CBG like the Mickey Kush Strain.

Source:

http://www.medicaljane.com/2013/08/03/cannabigerol-cbg-is-a-minor-cannabinoid-with-major-impact/

http://www.ncbi.nlm.nih.gov/pubmed/25269802

http://www.sciencedirect.com/science/article/pii/S0006295213000543

http://www.google.com/patents/CA2655094C?cl=en

http://www.amazon.com/Cannabis-Therapeutics-HIV-AIDS-Journal/dp/0789016990/ref=sr_1_1?s=books&ie=UTF8&qid=1418758497&sr=1-1&keywords=9780789016997

http://onlinelibrary.wiley.com/doi/10.1111/j.2042-7158.1989.tb06345.x/abstract

Cannabis and How it Helps Anxiety

 

Cannabis Treatment for Anxiety

  Anxiety is a natural experience for most of us. It makes us feel uneasy, stressed and agitated. When anxiety disables someone from carrying on a normal life, it becomes a disorder.  Cannabis is a safe and natural way to cope with the symptoms of Anxiety Disorder. OUTCOin San Diego is a legally licensed dispensary which provides cannabis for a variety of medical issues, including Anxiety Disorder.

What is an Anxiety Disorder
  Anxiety disorder can occur as a panic, social, phobia or a generalized worry that won't go away. Symptoms include fear, panic, insomnia, quick breath, racing heart, inability to self-sooth, dry mouth, nausea, tense muscles, dizziness, and clammy or numb hands and feet. Environmental stress, heredity, and trauma are factors that contribute to this disorder.

Anxiety and the Brain
  Receptors in the brain that control fear and emotion contribute to the feeling of anxiety.  Prolonged stress can alter the way these nerve cells transmit information leading to a long lasting anxiety disorder.(Source)

  Commonly prescribed drugs to treat anxiety such as Valium and Librium block the GABA receptors. When these receptors are blocked, the body can calm anxiety and fear-based emotions.  Cannabis has been shown to regulate anxiety by blocking the GABA receptor.(Source)

  The CB1 receptor also controls anxiety in the brain functions.  Studies have shown that regulating the CB1 receptor reduces anxiety.(Source) Cannabis has been continually proven to affect the CB1 receptorthrough research studies.(Source) Cannabis regulates mood and anxiety by controlling the CB1 receptors.(source) 

   Sachin Patel, M.D., Ph.D., professor of Psychiatry and Molecular Physiology and Biophysics in Vanderbilt, has been at the forefront of research for the benefits of cannabis relating to brain function. Published in the March 2014 issue of Neuron he writes about endocannabinoids in the amygdala. The amygdala regulates memory, anxiety and the "fight or flight" response in the brain.

   Long term stress and trauma can result in a reduction of endocannabinoids being produced in the amygdala resulting in an increased feeling of anxiety. Light users of marijuana can experience treatment in anxiety by increasing the endocannabinoids needed to regulate the emotion. In contrast, chronic marijuana users reduce the effectiveness of the endocannabioids creating a paradox of an increase in anxiety.(Source) 

   Cannabis regulates the brain function to aid in the treatment of anxiety disorder.  OUTCO dispensary in San Diego has knowledgeable staff that can discuss which options are right for each patient.

Source:
http://www.webmd.com/anxiety-panic/guide/mental-health-anxiety-disorders
http://thebrain.mcgill.ca/flash/d/d_04/d_04_m/d_04_m_peu/d_04_m_peu.html
http://outcoca.blogspot.com/2014/11/how-marijuana-effects-gaba-in-nervous.html
http://www.ncbi.nlm.nih.gov/pubmed/23647582
http://www.ncbi.nlm.nih.gov/pubmed/16148437
http://news.vanderbilt.edu/2014/03/discovery-sheds-new-light-on-marijuana-anxiety-relief-effects/

Cannabis Strains that are High in CBD

Most cannabis strains on the market are bred for their cannabinoid potency in THC, which is the active part that give a psycho effect. There are 85 active cannabinoids that are known in cannabis and cannabidiol or CBD is growing in popularity for it's high effectiveness for medicinal use without the psycho-active properties.

Treatment with Cannabidiol CBD

Cannabidiol in marijuana is the second most prevalent cannabinoid behind THC. At first it was thought the only benefit of CBD was to counteract the stoned effect that THC gives. However, CBD has been shown in research to give anti-inflammatory, analgesic and lower anxiety without the psycho-active effects that THC gives. These benefits have shown promising results for treatment in crohn's disease, PTSD, multiple sclerosis and a form of epilepsy called Dravet's Syndrome. Strains high in THC are usually at levels of 20% above, where CBD over 4% are known to be in high concentration. The FDA is approving a study this year to look at the effectiveness of CBD in children to hopefully make this a more accessible treatment.(Source)

Many patients are vocal about the importance of THC with CBD for complete effectiveness as a treatment. The government has acquired a patent for the benefits in THC, and research has showed it to help with appetite loss, nausea, multiple sclerosis and pain. Allowing to manage the percentage amount of THC and CBD gives the most effectiveness as well as also having control of how it is consumed. (Source)

Strains that are High in CBD

   The strains listed give different concentrations of CBD to THC ratios and also differentiate with their terpene properties to give different medicinal effects.

AC/DC - Sativa dominant 1:20 ratio of THC:CBD, a phenotype of Cannatonic

Cannatonic – Hybrid with 1:1 ratio. Origins are MK Ultra X and G-13 Haze.

Canna Sue – 13.8%CBD to 10.4%THC from Southern Humbolt Seed Company cross of Canna Tonic and Sour Tsunami

Charlotte's Web – Sativa dominant created by the Stanley brothers

Harlequin – Sativa Hybrid, registered 11.6%CBD to 8.4%THC (Source)

Harle Sue – Sativa Hybrid, registered 9.4%CBD to 6.7%THC, cross of Harlequin and Sour Tsunami

Jamaican Lion – Sativa with 1:1 ratio or better, cross between Mountain Lion and Yarders.(Source)

Omrita Rx – Indica dominant, 9.5% CBD to 11% THC, lots of leaves to juice, High in Beta Caryophylline.

Oracle* found to be identicle to AC/DC

Sour Tsunami – Sativa hybrid with 7.24%CBD to 4.32%THC ratio from Humboldt Seed Company

Women's Collective Stinky Purple

Swiss Gold – Sativa hybrid 7.2%CBD and 3.6%THC

Valentine X – Hybrid known to be highest CBD ratio 25:1, a phenotype of AC/DC

(Source)(Source)

Source:

http://www.projectcbd.org/medicine/strain-library/

http://www.leafly.com/news/lifestyle/whats-the-deal-with-these-high-cbd-strains

http://www.mpp.org/assets/documents/low-or-no-thc-high-cbd.html

http://synergycbd.com/cdb-rich-strains/

http://www.hydrocanna.com/showthread.php?t=9683

How Marijuana Effects GABA in the Nervous System

In short, GABA is a neurotransmitter in the mammal central nervous system that can repress excitability in the neurons in the nervous system and regulation in muscle tone. GABA is an abbreviation for gamma-Aminobutyric Acid which is an amino acid, which are secondary to water to being the biggest component in cells, tissue and muscle that are critical to biosynthesis and being a neurotransmitter. Cannabis plays a crucial role with the endocannabinoid system in suppressing the GABA, aiding in increasing dopamine levels which can help in treatments with medical marijuana.

GABA acts differently in stages of life, playing a roll in the developing brain as an excitatory component in the brain, while in adulthood acting as an inhibition in the brain. GABA regulates embryonic and neural stem cell growth. GABA has been found in the intestine, stomach, pancreas, fallopian tubes, uterus, ovaries, testis, kidney, bladder, lung, liver, lungs, melatonin and eye lens.(Source)

GABA makes up 40% of nerve cells, where glutamate makes up 30%. Glutamate offers excitability to the nervous system and also the brain synthesizes glutamate into GABA, which regulates the excitability, causing a check and balance, or ying and yang effect of controlling the functions. GABA inhibits nerve cells from growing, aggressive behavior, and regulates hyperactivity. (Source)

How Marijuana Inhibits GABA

Marijuana use effects the neurotransmitter GABA by blocking it. The result is increasing dopamine levels which normally GABA inhibits or regulates. Dopamine offers a mood shift of reward for the brain that is released with sex, exercise, appetite, learning, sleep, movement and mood.(Source)

Cannabis effects the cannabinoid receptors, namely Cb1 and Cb2 that mimic a naturally created endogenous molecule, anadamide. Anadamide is an Omega 6 fatty acid that regulates appetite, cognition, emotion, memory, mood and pain. Delta-9-tetrahydrocannabinol (THC) and other Cannabinoids found in marijuana can effect anadamide and therefore effect the endocannabinoid central nervous system.

THC, for instance, binds to the CB1 receptors, which reduces the enzyme cAMP which results in less protein kinase A. This results in potassium and calcium channels that ends up reducing the amount of neurotransmitters being released. This chemical reaction is the result of reducing GABA. A reduction in GABA results in an increase in dopamine. Dopamine do not effect the CB1 receptors. (Source)

Treatments From Inhibiting GABA

Research is still needed for more conclusive results, but promising studies and theories show that cannabis can be an effective treatment for it's ability to effect GABA including:

• Tinnitus – A brain induced ringing in the ear.

• Fibromyalgia – Tenderness in joints, muscles and other soft tissues.

• Anxiety – Stress inducing fear, unease and worry.

• Addiction – The difficulty to stop using substances.

• Schizophrenia – Difficulty knowing what is real and not, thinking clearly to have normal responses.

Source:

http://en.wikipedia.org/wiki/Gamma-Aminobutyric_acid

http://www.leafscience.com/2014/05/10/marijuana-dopamine-science/

http://countyourculture.com/tag/gaba/

http://thebrain.mcgill.ca/flash/i/i_03/i_03_m/i_03_m_par/i_03_m_par_cannabis.html

Cannabis and PTSD

OUTCO offers medical cannabis to PTSD sufferers in San Diego.  Research studies has shown that it is an effective treatment because of the way marijuana relates to the brain activity.

What Is PTSD

Post-Traumatic Stress Disorder, or PTSD can develop after a trauma that can cause flashbacks, memory loss of the event, anxiety or hyper-arousal for over a month. Common traumatic events could be war, injury, sexual assault, threats or witness to a traumatic event. Women are more likely to get PTSD and children under the age of 10 rarely experience it. (Source)

Correlation of PTSD and Marijuana Use

An increased tendency to use in marijuana occurs with PTSD sufferers than the general public. A study showed that with teen and young adults, PTSD contributed to the use of cannabis more than peer pressure or other factors.(Source) Another study with 5,672 adults showed that the relation to PTSD symptoms and the use of cannabis were directly correlated. (Source)

PTSD, Cannabis and the CB1 Brain Receptor

Defective CB1 receptor signaling in the brain appear to be the cause of memories to not diminish in impact over time. Studies with animals have shown that this malfunction in the receptor due to trauma can cause anxiety, fear and depression symptoms leading to insomnia, isolation and other effects.(Source) Research has shown that enhancing cannabinoids receptors in the brain reduce the anxiety and fear symptoms in animals.(Source)

Tetrahydrocannabinol (THC) and cannabidiol (CBD) in cannabis show a relation in allowing the CB1 and CB2 receptors to work by inhibiting the enzyme fatty acid amide hydroxylase (“FAAH”) from destroying the endogenous cannabinoid neurotransmitter, Anandamide. Anandamide is based off of a sanskrit word meaning joy, bliss and delight and has been known at low levels to decrease pleasure and motivation. (Source)

OUTCO is the only licensed marijuana dispensary in San Diego to aid PTSD sufferers with Cannabis treatment. Cannabidiol CBD offers treatment without the psychoactive effects of THC. We offer free delivery and medicine at affordable prices for patients. Look for our future blog on how the Veteran community is helped by OUTCO in San Diego.

Source

http://en.wikipedia.org/wiki/Posttraumatic_stress_disorder

http://www.sciencedirect.com/science/article/pii/S0306460309002366

http://psycnet.apa.org/journals/adb/25/3/554/

http://onlinelibrary.wiley.com/doi/10.1002/da.22031/abstract

http://www.ncbi.nlm.nih.gov/pubmed/15637635

http://en.wikipedia.org/wiki/Anandamide