The Link between Cannabis and Breast Milk

Babies with their pacifiers and munchies after marijuana may go hand in hand. Cannabis and breast milk both effect the endocannabinoid system. Cannabinoids aid the body in creating a stable internal environment. The cannabinoids in breast milk provide health benefits that help babies grow and thrive.

A human embryo at 14 weeks of gestation starts forming cannabinoid receptors. By twenty weeks, the receptors grow at a rapid rate and start to function. Research suggests that the early formation helps to mature the nervous system.(Source)

The 2004 European Journal of Pharmacology article stated that "endocannabinoids have been detected in maternal milk and activation of CB1 (cannabinoid receptor type 1) receptors appears to be critical for milk sucking.”(Source) The desire to suck is integral to the life-affirming need for nourishment.

Some of the same active cannabinoids found in marijuana are in high concentration in breast milk. The endocannabinoid system boosts immunity, reduces inflammation, relieves pain, and increases appetite by regulating the internal systems of the body.

Source:

http://www.sciencedirect.com/science/article/pii/S0014299904007423

http://pharmrev.aspetjournals.org/content/58/3/389.full#title49

http://www.naturalnews.com/036526_cannabinoids_breast_milk_THC.html

http://www.cannabiscure.info/files/cannabis_breastmilk.htm

Cannabis Use to Treat Eczema and Psoriasis

Many people that use cannabis to help with eczema and psoriasis. Marijuana helps with skin irritations by reducing inflammation. One third of the world population is thought to suffer from eczema.(Source)

Hemp seed, rich in linolenic acid (both α- and γ-), has shown benefits for reducing inflammation.(Source) Gastrointestinal problems have shown to increase skin problems. When the intestinal tract fails to absorb linolenic acid it is thought that skin abnormalities occur. Studies have shown that cannabis helps with gastrointestinal issues.

Auto immune deficiency can lead to skin abnormalities. Cannabis increases overall body immunity by being rich in globulin edestin. Immunity is increased by how it effects the endocannabinoid system, anandamide, and the 2-AG receptor.

Many dietary sources are rich in linolenic acid. Cannabis sets itself above the rest by the way it effects the endocannabinoid system. Abnormalities of cells attribute to skin problems. The endocannabinoid system regulates the cell proliferation, death and differentiation to maintain a homeostasis state.

http://sensiseeds.com/en/blog/cannabis-chrohttp://informahealthcare.com/doi/abs/10.1080/09546630510035832nic-skin-conditions/

http://www.ncbi.nlm.nih.gov/pubmed/17498413

http://informahealthcare.com/doi/abs/10.1080/09546630510035832

How Cannabis Improves Memory

Cannabis and Memory

Cannabis affecting the endocannabinoid system plays a role in memory and cognitive functioning. This is due to CB1 receptors in the endocannabinoid system contributing to retrograde signaling in the brain. Researchers are studying how this relation can aid in treatment to depression and PTSD.

A main study to discover this relation is from mice that were engineered to not have the CB1 receptor. The mice were impaired in short-term and long-term extinction of memories. Their cognition of new hidden mazes also showed their disability in learning.(Source)

Extinction of memories may seem at first as a bad thing. However, our brain does this continually to allow us to see new avenues of thinking. In the mice example the CB1 deficient mice continued to look for the old way out of their cage. They weren't able to allow themselves to discover a new door. Depression and PTSD may improve the ability to forget long term memories.(Source)

The ability to improve cognitive thinking has given cannabis a reputation to flourish creative thinking. CB1 receptors play a role with use of marijuana to increase dopamine levels. This change allows for white noise of the environment to be reduced to give rise to focus and concentration.(Source)

Source:

http://en.wikipedia.org/wiki/Cannabis_and_memory

http://veteransformedicalmarijuana.org/content/general-use-cannabis-ptsd-symptoms

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2571074/

How Cannabis Effects the Endocannabinoid System

Cannabis has a profound effect on our body due to it's influence on our endocannabinoid system. The origin of its name comes from the cannabis plant. It is a system of lipids and receptors that maintain health creating a homeostasis environment in the body. The endocannabinoid system is found throughout our body in the brain, organs, connective tissues, glands and immune cells. The prevalence of the endocannabinoid system in the body is the reason cannabis can treat many diverse diseases and symptoms.

Environmental factors can cause disruption in the bodies health. Stability is brought back with the endocannabinoid system. The goal for the lipids and receptors are to stabilize numerous body functions including appetite, pain, inflammation, mood, memory, muscle spasms, protect nerves, immunity, and bone density. Cannabis would be the closest cure-all for its ability to affect so many functions in the body.

The endocannabis system is made up of ligands like anandamide and 2-arachidonoylglycerol (2-AG). The cannabinoid CB1, CB2, TRPV1 and G protein-coupled receptors are part of the endocannabinoid system. Together these ligands and receptors control the stabilization of the body.

Cannabis can encourage more endocannabinoids and receptors to be made by the body. First-time users of cannabis may not feel an effect from cannabis. As the body increases cannabinoids it responds more effectively to a cannabis treatment. Smaller doses have larger effects for the receptors to respond to marijuana.(Source)

Source:

http://en.wikipedia.org/wiki/Endocannabinoid_system

http://norml.org/library/item/introduction-to-the-endocannabinoid-system

Cardiovascular Effects from Cannabis

Cardiovascular Effects from Cannabis

Studies have shown that marijuana in humans can increase heart rate and blood pressure moderately with first initial use. With regular use of cannabis these initial cardiovascular effects rapidly go away. Regular exposure to cannabis shows results of reduced blood pressure, reduced heart rate and increased vasodilation.(Source) Lowered heart rate and blood pressure is also seen in animals studies with cannabis.(Source)

Cannabinoids affect a group of lipids and receptors that control the endocannabinoid system. Anandamide is an endocannabinoid messenger molecule that helps control the heart rate and blood pressure. One way it effects the cardiovascular system is by vasodilation, or enlarging the blood vessels. Vasodilation occurs from a relaxation of artery walls to allow a larger volume of blood flow.(Source)

Dr. Phillip Leveque leads a medical marijuana doctor group with over 100,000 patients. They have found the increase in heart rate and blood pressure to be low and tolerable. In their group they have no reports of dangerous clinical hypertension. For his personal patients they average an age of 48 and have a lower percentile of hypertension than most people of that age not using marijuana.(Source) The first use of cannabis has shown to be safe for patients but still advised to be recommended by a doctor.(Source)

Source:

http://www.ncbi.nlm.nih.gov/pubmed/11106789

http://norml.org/library/item/hypertension

http://circ.ahajournals.org/content/110/14/1996.full

http://onlinelibrary.wiley.com/doi/10.1002/j.1552-4604.2002.tb06004.x/abstract

http://www.salem-news.com/articles/march142010/hypension-mmj.php

How Marijuana Effects GABA in the Nervous System

In short, GABA is a neurotransmitter in the mammal central nervous system that can repress excitability in the neurons in the nervous system and regulation in muscle tone. GABA is an abbreviation for gamma-Aminobutyric Acid which is an amino acid, which are secondary to water to being the biggest component in cells, tissue and muscle that are critical to biosynthesis and being a neurotransmitter. Cannabis plays a crucial role with the endocannabinoid system in suppressing the GABA, aiding in increasing dopamine levels which can help in treatments with medical marijuana.

GABA acts differently in stages of life, playing a roll in the developing brain as an excitatory component in the brain, while in adulthood acting as an inhibition in the brain. GABA regulates embryonic and neural stem cell growth. GABA has been found in the intestine, stomach, pancreas, fallopian tubes, uterus, ovaries, testis, kidney, bladder, lung, liver, lungs, melatonin and eye lens.(Source)

GABA makes up 40% of nerve cells, where glutamate makes up 30%. Glutamate offers excitability to the nervous system and also the brain synthesizes glutamate into GABA, which regulates the excitability, causing a check and balance, or ying and yang effect of controlling the functions. GABA inhibits nerve cells from growing, aggressive behavior, and regulates hyperactivity. (Source)

How Marijuana Inhibits GABA

Marijuana use effects the neurotransmitter GABA by blocking it. The result is increasing dopamine levels which normally GABA inhibits or regulates. Dopamine offers a mood shift of reward for the brain that is released with sex, exercise, appetite, learning, sleep, movement and mood.(Source)

Cannabis effects the cannabinoid receptors, namely Cb1 and Cb2 that mimic a naturally created endogenous molecule, anadamide. Anadamide is an Omega 6 fatty acid that regulates appetite, cognition, emotion, memory, mood and pain. Delta-9-tetrahydrocannabinol (THC) and other Cannabinoids found in marijuana can effect anadamide and therefore effect the endocannabinoid central nervous system.

THC, for instance, binds to the CB1 receptors, which reduces the enzyme cAMP which results in less protein kinase A. This results in potassium and calcium channels that ends up reducing the amount of neurotransmitters being released. This chemical reaction is the result of reducing GABA. A reduction in GABA results in an increase in dopamine. Dopamine do not effect the CB1 receptors. (Source)

Treatments From Inhibiting GABA

Research is still needed for more conclusive results, but promising studies and theories show that cannabis can be an effective treatment for it's ability to effect GABA including:

• Tinnitus – A brain induced ringing in the ear.

• Fibromyalgia – Tenderness in joints, muscles and other soft tissues.

• Anxiety – Stress inducing fear, unease and worry.

• Addiction – The difficulty to stop using substances.

• Schizophrenia – Difficulty knowing what is real and not, thinking clearly to have normal responses.

Source:

http://en.wikipedia.org/wiki/Gamma-Aminobutyric_acid

http://www.leafscience.com/2014/05/10/marijuana-dopamine-science/

http://countyourculture.com/tag/gaba/

http://thebrain.mcgill.ca/flash/i/i_03/i_03_m/i_03_m_par/i_03_m_par_cannabis.html