Rick Simpson Oil

Rick Simpson Oil

Rick Simpson Oil (RSO) is named after the developer of the famous product. Rick Simpson created the oil to cure his cancer. Many others have cited the nutrient rich oil as a cure for their own cancer.(Source)

A full spectrum of cannabinoids are present in Rick Simpson Oil, most notably THC. The benefits of the cannabinoids together give different medicinal effects than CBD Oil. (Source) Also named Phoenix Tears, RSO is made from a recipe that is available on Rick Simpson's website. The oil uses Indica strain flowers, so the color varies with each batch. Patients can ingest the oil or apply it directly on the skin for targeted relief.

When starting out with RSO, ingest a small amount (approx. the size of a grain of rice). The oil is very potent and should only be used when you’re not working or driving. Once you start your treatment, you will build a tolerance - with time, you will be able to take more RSO in a single dose. (Source)

Source:

http://www.zamnesia.com/content/361-the-difference-between-cbd-oil-and-rick-simpson-oil

http://phoenixtears.ca/what-it-does-and-how-it-works/

http://boards.cannabis.com/threads/my-experience-with-rick-simpson-oil.200017/

Casa Luna CBD Edibles

Casa Luna Edibles

There is nothing better than nourishing your body while indulging in delight! Casa Luna handcrafts their chocolate bars with quality ingredients, infusing their treats with anti-oxidants to boost your health. They are also unique as they add cannabidiol (CBD) so patients can doubly enjoy their medicine.

Casa Luna controls every aspect of production, from the cocoa bean seed to the final product. The chocolate is 100% organic and made with kosher certified ingredients. Grown on family-owned small farms, the cocoa bean goes through a process of fermenting, drying, and roasting to release the chocolate’s flavors.

A wide assortment of Casa Luna chocolate bars are available at Outliers Collective. Super foods (such as Goji Berries, Maca, and Pomegranate) are infused in the chocolate for an added health boost. Vegan and sugar free chocolate is also available.

Testimonial - Anxiety

Medical Marijuana Testimonial	I dealt with anxiety for most of my adult life.  Most cannabis made that worse.  After trying  xanax, valium, alcohol, none of them were a palatable solution. Then I bought some ACDC at Outco and found nature's cure to anxiety disorders.  It is a high CBD strain (20:1) and they have others as well.  Also, now that my anxiety is dealt with, I also enjoy the other medicinal benefits of cannabis.  Thanks for making quality medicinal strains available to San Diego County all done within the confines of the law.
Strains you Like	ACDC, Mr. Nice, Skywalker OG, Donna OG, Cannatonic, Harlequin, Harle-Tsu, Jack Herer
Conditions
Symptoms	Anxiety Depression Insomnia

Outliers Collective Proudly Carries Cibaderm Personal Care Products

Cibaderm Hemp CBD Lotions and Hair Care

Cibaderm Hemp CBD Lotion and Hair Care Products

Cibaderm Hemp CBD lotions and hair care are now available in San Diego at Outliers Collective. Their signature extraction of the hemp plant makes your nails, skin and hair healthier and radiant. The steam-distilled botanicals soothe your skin and hair to nourish and protect.

Cibaderm Hemp Hydrate Hand Cream

One of the quickest way to show your age is in the delicate skin on your hands. Cibaderms Hemp CBD Complex hydrates and protects the skin. Powerful antioxidants like Vitamin E help to protect from sun damage and reduce signs of aging.

Cibaderm Hemp Nourish Body Lotion

Cibaderms Body Lotion brings your skin back to a baby soft and smooth feeling. It absorbs quick with a superb moisturizing formula to relieve dry skin.

Cibaderm Hemp Fresh Body Wash

Cibaderm Body Wash is great for showering to make your skin feel energized. It soothes the mind and body with it's rich botanicals to give your skin its natural glow.

Cibaderm Hemp Soft Conditioner

Cibaderm Conditioner strengthens while conditions the hair naturally. Added botanicals give full day protection from the sun, wind and hair products. Great for all hair types, the weightless conditioner reveals your hairs shine.

Cibaderm Hemp Clean Shampoo

Great for all hair types the Cibaderm Shampoo gives back your hairs luminescence. Free from harsh chemicals and sulfates it gives a cleansing that allows your hair to be manageable. Cibaderms Shampoo can be used with color or treated hair.

Pediatricians Urge the Government to Accept Cannabis Medication

In 2015 pediatricians started out with positive pressure to reclassify marijuana. The American Academy of Pediatrics urged the U.S. Drug Enforcement Agency for more research into the benefits of cannabis medication. They also called for compassion for their patients to use marijuana.

Doctors and parents have seen beneficial uses of cannabis for children. Cannabis rich in the cannabinoid CBD has shown to reduce epileptic seizures in children with dravet syndrome. Some cases have shown that CBD has also reduced brain tumors in children. Cannabis use has also shown to help with autism in verbal communication and reducing self injury.(Source)

Currently the government has taken steps to legitimize it as a beneficial drug. The government holds a patent for the beneficial use of cannabis. Prescribed cannabis medication like Dronabinol and Sativex are out on the mainstream market for treatment in nausea, neuropathic pain, spasticity and overactive bladder. The U.S. Governement owns a marijuana farm at the University of Mississippi for research.

The AAP wants to specifically change the way cannabis is classified as a schedule 1 drug. This current classification restricts marijuana from research and use as a medication to the public.

Source:

http://www.wsj.com/articles/BL-270B-1364?utm_content=bufferdcc0e&utm_medium=social&utm_source=twitter.com&utm_campaign=buffer

https://faceofcannabis.wordpress.com/2013/10/24/calvin/

What Cannabis Sprays Are Used For

Cannabis Sprays

Cannabis spray is an oral medication for pain. In 2014 the FDA designated a fast track to approve cannabis sprays at a federal level. Cannabis sprays are desired by cancer patients that have trouble responding to opiate medication for their pain.

The company GW Pharmaceuticals has become well known for cannabis based drugs for the mainstream market. Their CEO Justin Gover says “Sativex is the only non-opioid treatment currently in Phase 3 development for patients who do not respond to, or experience negative side effects with opioid medications.” He goes on to say “We are fully committed to delivering the first FDA-approved cannabinoid medicine for these patients who currently have nowhere else to turn.”(Source)

Many patients prefer the spray over other cannabis applications. The benefits of administering an oral spray are the fast acting effects. Cannabis spray is discreet and has a pleasant smell. The sprays are offered in unflavored or other flavors like mint. Patients can regulate their dosage in an effective way with the spray.

OUTCO currently offers CBD oil spray in unflavored or peppermint flavor. Outliers Collective is located in El Cajon. It is the only legally licensed Dispensary in San Diego.

Source:

http://www.hightimes.com/read/fda-yes-marijuana-spray-will-not-reclassify

Harlequin Strain

Harlequin Marijuana Strain is High in CBD

Harlequin strain is for patients of medical marijuana looking for high pain relief. Harlequin is known for its high potency of the cannabinoid CBD. A ratio of 5:2 CBD to THC gives medication that is low in psycho-active sedation. Having some THC allows for the analgesic to be more effective than other strains that are void of THC. Harlequin is 75% sativa dominant which gives the effects of alertness while giving the ability to relax.

The Harlequin strain is a cross between the Columbian Gold, Swiss and Thai sativa with a Nepalese Indica Landrace strain. The smell has been described as sweet and tropical while the taste is fairly bland to sweet. The buds are thick with trichome orange hairs which overtake the green in the bud. Most strains while being cultivated increase in CBD while maturing. Harlequin is unique in that its highest concentration of CBD is earlier and diminishes with maturity.

OUTCO typically stocks Harlequin as a tincture for patients. Our staff in El Cajon just outside of San Diego is knowledgeable and compassionate to care for their members needs. Patients describe Harlequin for helping pain, seizures, anxiety, stress, nausea and muscle spasms. Please stop by or contact us for individual attention to your questions and needs.

Source:

http://www.leafly.com/sativa/harlequin

http://www.marijuana.com/news/2013/08/harlequin-marijuana-strain-review-and-photos-high-in-cbd-low-in-thc/

The Differences Cannabis Raw, Heated or Aged

The Differences Cannabis Raw, Heated or Aged

Different cannabinoids are created when the flower is exposed to UV light, aging, oxidation and heat. Each cannabinoid has unique medicinal effects.

Cannabis is unique in that it is the only plant able to produce cannabigerolicacid (CBGa). The first cannabinoid the cannabis plant produces in raw form is CBGa. Cannabis synthesizes through natural enzymes to change CBGa into three main cannabinoid branches. CBGa is in an unstable form and typically is converted to other cannabinoids quickly. These three cannabinoids types are tetrahydrocannabinolic acid (THCa), Cannabidiolic acid (CBDa) and Cannabichromenic acid (CBCa).

Heat changes cannabinoids into THC, CBD, CBG and CBN. This conversion process is created by losing a carbon dioxide molecule (CO2). In this state they are thought to be in a neutral form. When a strain has a high CBGa content smoking it will add heat and change it to CBG.

Raw or heated cannabis can turn into different cannabinoids when it has oxidation and age. THCa with oxidation will change to CBNa. Aged THC will change into CBN or Tetra8 THC. When aged CBC will turn into CBL. Raw CBCa turns into CBLa over time.

CBD Tinctures

CBD Tinctures at OUTCO

OUTCO offers CBD Tinctures at the El Cajon Dispensary or Free Delivery for your convenience. Patients describe Cannabidiol (CBD) as treatment for pain, depression, anxiety, muscle spasms, and inflammation. Clinical research has shown CBD to be anti-bacterial, reduce cancer cells, a bone stimulant and a neuroprotectant. CBD is the cannabinoid in marijuana that has the most known benefits without a psychotic effect.

Typically patients use the tincture by putting 1-3 drops under their tongue. More drops can be used as needed. OUTCO has a proprietary method of extracting the CBD to a high concentrated form. Tinctures come in a choice of glycerin or alcohol. Glycerin patients describe as tasting better, while alcohol seems to provide more immediate relief.

The Medicinal Properties of Cannabinoids

  

Cannabinoid Treatment

  Medicinal properties in the cannabis plant come from cannabinoids. At least 85 different cannabinoids have been isolated in the plant. The most researched cannabinoids are tetrahydrocannabinol (THC), cannabidiol (CBD) and cannabinol (CBN).(Source)

     Marijuana users get excited to see a sticky white resin on the flower buds because they contain most of the cannabinoids. They are produced from glandular hairs (trichomes) on the flower. Cannabinoids imitate naturally produced endocannabinoids in our body that maintain health.(Source)

    Cannibinoids interact with one another to provide different medicinal effects. Based on the understanding of cannibinoids, dispensaries like OUTCO administer a variety of cannabis medications. Listed below is the different cannabinoids and their specialized treatments.

Tetrahydrocannabinol (THC) – The psycho-active cannabinoid that treats pain, nausea, muscle spasms, anxiety and increases appetite.

Cannabidiol (CBD) – The most beneficial cannabinoid aiding in pain, slowing bacerteria growth, reducing sugar levels, nausea, reducing seizures, inflammation, insomnia, artery blockage, cancer cells\tumors, psoriasis, muscle spasms, anxiety, osteoporosis, increases immunity, spasms in intestine and protecting the nervous system.

Cannabigerolic (CBG) – Reduces bacteria growth, inflammation, cancer cells\tumors, and osteoporosis.

Cannabinol (CBN) – Mildly psycho-active that treats pain, insomnia, and muscle spasms.

Cannabichromene (CBC) – Has been shown to reduce pain including migraines, inflammation, cancer cells\tumors and osteoporosis.

Tetrahydrocannabivarin (THCv) – Mildly psycho-active that gives a euphoria and intensifies THC. Known to help with weightloss, reducing seizures, and osteoporosis.

THCa – Known to reduce inflammation, cancer cells\tumors, and muscle spasms.

Cannabigerolic acid (CBGa) – Aquired when consumed raw to reduce pain, inflammation, slow bacteria growth and reduce cancer cells\tumors.(Source)

CGCa – A cannabinoid known to reduce inflammation.

CBCa – Slows bacterial and fungal infection.

CBDa – Reduces cancer cells\tumors and inflammation.

Source:

http://en.wikipedia.org/wiki/Cannabinoid

http://www.leafly.com/knowledge-center/cannabis-101/cannabinoids-101-what-makes-cannabis-medicine

http://www.420magazine.com/forums/cannabis-facts-information/76763-marijuana-cannabinoids-thc-cbd-cbn.html

http://theleafonline.com/c/science/2014/08/cannabinoid-profiles-crash-course-cbga/

Did Jesus Use Cannabis

OUTCO welcomes all religions and we hope to continue to investigate the history of the usage of cannabis throughout many religions and different time periods playing a role in society.

Lost in translation has kept many historians from having a definitive explanation of the biblical passages that may have been talking about cannabis. There are reasons to believe that cannabis was the healing and anointing oil rich in CBD that is talked about in the Bible. There is also skeptics who believe that the translation was correct, and cannabis was not referenced in the Bible. Hemp has been grown since 6000BC and was around and prevalent in the time of Christ. Some of the miracles Jesus preformed are also similar to treatments for cannabis including skin diseases, glaucoma, neurodegenerative conditions and multiple sclerosis.

An error was thought to have occurred in the third century BC oldest Greek translation of the Hebrew Bible. The translation put the word as calamus, which Benet believes is a common marsh plant with no value and doesn't go along with the importance it was given in the Bible. This word calamus was mistranslated five times in the Old Testament, Exodus, Ezekiel, Isaiah, Jeremiah, and Song of Songs.

In 1936 Sula Benet, a Polish etymologist proclaimed that the word cannabis is much older than the first thought Scythian origin, and believes it to be from Semitic Hebrew language, appearing throughout the Old Testament. Benet points out that in the testament it is described as incense, part of religious celebration, and an intoxicant. Benet went on to show that the word in the Old Testament, Kannabus or kaneh-bosm, broken down where Kan meant “reed” or “hemp” and bosm meaning “aromatic”.(Source) 

Exodus 30:22 – 25 talks about the recipe Lord gave Moses for healing oil:

“Moreover, the LORD spoke to Moses, saying, "Moreover the LORD spake unto Moses, saying,
Take thou also unto thee principal spices, of pure myrrh five hundred shekels, and of sweet cinnamon half so much, even two hundred and fifty shekels, and of sweet calamus two hundred and fifty shekels, And of cassia five hundred shekels, after the shekel of the sanctuary, and of oil olive an hin: And thou shalt make it an oil of holy ointment, an ointment compound after the art of the apothecary: it shall be an holy anointing oil.”(Source)

Another theory to speak to the importance of the anointing with oil for the religion is brought out in the Book of Philip, which is a book that is part of The Nag Hammadi Library not recognized by the Roman Catholic Church. One of the passages states:

“The chrism is superior to baptism, for it is from the word "Chrism" that we have been called "Christians," certainly not because of the word "baptism". And it is because of the chrism that "the Christ" has his name. For the Father anointed the Son, and the Son anointed the apostles, and the apostles anointed us. He who has been anointed possesses everything. He possesses the resurrection, the light, the cross, the Holy Spirit. The Father gave him this in the bridal chamber; he merely accepted (the gift). The Father was in the Son and the Son in the Father. This is the Kingdom of Heaven.”(Source)

All of this evidence is compelling, including the Lytton John Musselman, a Professor of Botany at Old Dominion University believes the translation has always been correct with the calamus plant. He points out that calamus is used as an herbal remedy. He notes, “In Sri Lanka it is available in any herbal remedy shop and also universally grown in home gardens. (Source) 

Source:

http://www.vice.com/read/did-jesus-perform-his-miracles-with-cannabis-oil

http://gnosis.org/naghamm/gop.html

biblehub.com/exodus/30-22.htm

Cannabis Strains that are High in CBD

Most cannabis strains on the market are bred for their cannabinoid potency in THC, which is the active part that give a psycho effect. There are 85 active cannabinoids that are known in cannabis and cannabidiol or CBD is growing in popularity for it's high effectiveness for medicinal use without the psycho-active properties.

Treatment with Cannabidiol CBD

Cannabidiol in marijuana is the second most prevalent cannabinoid behind THC. At first it was thought the only benefit of CBD was to counteract the stoned effect that THC gives. However, CBD has been shown in research to give anti-inflammatory, analgesic and lower anxiety without the psycho-active effects that THC gives. These benefits have shown promising results for treatment in crohn's disease, PTSD, multiple sclerosis and a form of epilepsy called Dravet's Syndrome. Strains high in THC are usually at levels of 20% above, where CBD over 4% are known to be in high concentration. The FDA is approving a study this year to look at the effectiveness of CBD in children to hopefully make this a more accessible treatment.(Source)

Many patients are vocal about the importance of THC with CBD for complete effectiveness as a treatment. The government has acquired a patent for the benefits in THC, and research has showed it to help with appetite loss, nausea, multiple sclerosis and pain. Allowing to manage the percentage amount of THC and CBD gives the most effectiveness as well as also having control of how it is consumed. (Source)

Strains that are High in CBD

   The strains listed give different concentrations of CBD to THC ratios and also differentiate with their terpene properties to give different medicinal effects.

AC/DC - Sativa dominant 1:20 ratio of THC:CBD, a phenotype of Cannatonic

Cannatonic – Hybrid with 1:1 ratio. Origins are MK Ultra X and G-13 Haze.

Canna Sue – 13.8%CBD to 10.4%THC from Southern Humbolt Seed Company cross of Canna Tonic and Sour Tsunami

Charlotte's Web – Sativa dominant created by the Stanley brothers

Harlequin – Sativa Hybrid, registered 11.6%CBD to 8.4%THC (Source)

Harle Sue – Sativa Hybrid, registered 9.4%CBD to 6.7%THC, cross of Harlequin and Sour Tsunami

Jamaican Lion – Sativa with 1:1 ratio or better, cross between Mountain Lion and Yarders.(Source)

Omrita Rx – Indica dominant, 9.5% CBD to 11% THC, lots of leaves to juice, High in Beta Caryophylline.

Oracle* found to be identicle to AC/DC

Sour Tsunami – Sativa hybrid with 7.24%CBD to 4.32%THC ratio from Humboldt Seed Company

Women's Collective Stinky Purple

Swiss Gold – Sativa hybrid 7.2%CBD and 3.6%THC

Valentine X – Hybrid known to be highest CBD ratio 25:1, a phenotype of AC/DC

(Source)(Source)

Source:

http://www.projectcbd.org/medicine/strain-library/

http://www.leafly.com/news/lifestyle/whats-the-deal-with-these-high-cbd-strains

http://www.mpp.org/assets/documents/low-or-no-thc-high-cbd.html

http://synergycbd.com/cdb-rich-strains/

http://www.hydrocanna.com/showthread.php?t=9683

The Benefits of Cannabis for Epilepsy

Cannabis with a high content of Cannabidiol CBD have been found to help treat epilepsy in some patients. A certain type of epilepsy, called Dravet Syndrome has shown the most promising treatment with marijuana than other types of epilepsy. Most treatment is administered with a cannabis oil from the Charlotte's Web Strain made by a non-profit organization Realm of Caring(Source), however much of the CBD rich cannabis administered gives similar treatment and different concentrations of CBD, THC and THCA are needed for a more precise treatment for the patient. Legislation and regulation of the medicine is targeting a CBD only medicine, but many believe it is the whole plant that offer the effects, not just the CBD cannabinoid.(Source)

Here is a compiled list of studies that show the benefits of Cannabis with Epilepsy:

September 2003 - The Journal of Pharmacology and Experimental Therapeutics - The Endogenous Cannabinoid System Regulates Seizure Frequency and Duration in a Model of Temporal Lobe Epilepsy
This study showed in rats that had epileptic seizures to be reduces or terminated with THC and CBD from the effect that the cannabinoids had on the CB1 Receptors.

March 2004 – US National Library of Medicine - Endocannabinoid Effects on Febrile Seizures: Not Just a Toke(n) Mechanism
This study showed that in rats a febrile seizure lasting up to 22 minutes was regulated or terminated with cannabis from it's ability to inhibit GABA, a form of neurotransmitters, which also shows that the result of seizures relies in the increase of GABA being released.

May 2004 – US National Library of Medicine - Cannabinoids: Defending the Epileptic Brain
Another study showing the benefits of Cannabis affecting mice in the CB1 receptors, using both the THC and CBD.

June 2004 – Neurology.org - Marijuana use and epilepsy
This is a telephone survey, calling people with epilepsy and finding if they have used marijuana treatment and their findings. 24% of patients called felt that marijuana was an effective treatment for their epilepsy.

November 2004 – ScienceDirect.com - On-demand activation of the endocannabinoid system in the control of neuronal excitability and epileptiform seizures
This study formulates a theory that certain types of seizures can be surpressed or increased with the cannabinoid system and how it regulates the GABA can help regulate the endocannabinoid system.

January 2006 – US National Library of Medicine - Endocannabinoids: A Critical Regulator of Activity in the Developing Brain
 Study showing that the theory that during pregnancy the interferance with marijuana to inhibit CB1 activity or an obesity drug that increases CB1 activity can disrupt the developing endocannabinoid system.

Marijuana and Epilepsy – page on Neuro Science Fundamentals This article talks about Charlotte Figi's story and the introduction of the Charlotte's Web strain to help treat epilepsy.
Edward Maa M.D, an assistant professor at the University of Colorado Department of Neurology,is conducting a study at University of Colorado Anshutz Medical Campus on epilepsy research. The study will separate epilepsy sufferers in two groups of whether the Charlotte's Web strain reduces the epilepsy symptoms by 50% and another group that the symptoms are not helped by the cannabis strain. He will do genetic analysis to find out what the differences in the epilepsy is to help target the marijuana to the correct patients.(Source)

On July 28^th, 2014 The Realm of Caring released the Charlotte's Web Medical Hemp Act of 2014 to legalize federally the CBD only oil for epilepsy. Many believe this is not a complete effort for treatment, Edward Maa is at the forefront in writing articles on how important it is for the treatment to use the whole plant, just not the isolated Cannabidiol CBD.(Source) Jason David, a parent treating his 7 year old son with epilepsy mentions in a report by ladybud.com that his son Jayden suffered from the wrong concentration of cannabinoids from the Charlotte's Web strain. He states:

“They’re not telling the whole truth,” says David. “There’s no way possible that all these children in Colorado could get seizure control and get off all their medications without using different ratios and adding THC and THCA (which are not allowed by the newly proposed legislation). Charlotte’s Web can work great in the beginning but it’s impossible to get off all the medications and go through benzo withdrawals without being able to play with the THC ratios.” (Source)

 
Source: http://time.com/3264691/medical-marijauna-epilepsy-research-charlottes-web-study/ http://onlinelibrary.wiley.com/doi/10.1111/epi.12610/abstract http://www.ladybud.com/2014/07/29/a-limited-amount-of-caring-parents-and-advocates-react-to-realm-of-carings-federal-cbd-only-bill/ http://theroc.us/index.php?option=com_k2&view=item&id=22:charlotte-s-web-medical-hemp-act-of-2014&Itemid=498

Cannabis and PTSD

OUTCO offers medical cannabis to PTSD sufferers in San Diego.  Research studies has shown that it is an effective treatment because of the way marijuana relates to the brain activity.

What Is PTSD

Post-Traumatic Stress Disorder, or PTSD can develop after a trauma that can cause flashbacks, memory loss of the event, anxiety or hyper-arousal for over a month. Common traumatic events could be war, injury, sexual assault, threats or witness to a traumatic event. Women are more likely to get PTSD and children under the age of 10 rarely experience it. (Source)

Correlation of PTSD and Marijuana Use

An increased tendency to use in marijuana occurs with PTSD sufferers than the general public. A study showed that with teen and young adults, PTSD contributed to the use of cannabis more than peer pressure or other factors.(Source) Another study with 5,672 adults showed that the relation to PTSD symptoms and the use of cannabis were directly correlated. (Source)

PTSD, Cannabis and the CB1 Brain Receptor

Defective CB1 receptor signaling in the brain appear to be the cause of memories to not diminish in impact over time. Studies with animals have shown that this malfunction in the receptor due to trauma can cause anxiety, fear and depression symptoms leading to insomnia, isolation and other effects.(Source) Research has shown that enhancing cannabinoids receptors in the brain reduce the anxiety and fear symptoms in animals.(Source)

Tetrahydrocannabinol (THC) and cannabidiol (CBD) in cannabis show a relation in allowing the CB1 and CB2 receptors to work by inhibiting the enzyme fatty acid amide hydroxylase (“FAAH”) from destroying the endogenous cannabinoid neurotransmitter, Anandamide. Anandamide is based off of a sanskrit word meaning joy, bliss and delight and has been known at low levels to decrease pleasure and motivation. (Source)

OUTCO is the only licensed marijuana dispensary in San Diego to aid PTSD sufferers with Cannabis treatment. Cannabidiol CBD offers treatment without the psychoactive effects of THC. We offer free delivery and medicine at affordable prices for patients. Look for our future blog on how the Veteran community is helped by OUTCO in San Diego.

Source

http://en.wikipedia.org/wiki/Posttraumatic_stress_disorder

http://www.sciencedirect.com/science/article/pii/S0306460309002366

http://psycnet.apa.org/journals/adb/25/3/554/

http://onlinelibrary.wiley.com/doi/10.1002/da.22031/abstract

http://www.ncbi.nlm.nih.gov/pubmed/15637635

http://en.wikipedia.org/wiki/Anandamide

The Different Types of Concentrates

The concentrates for cannabis are growing in popularity with it outselling the traditional buds in retail lately. Much of this change is in the popularity of Vape Pens and different forms of using marijuana such as edibles. Concentrates are just like the name refers to, a concentrated form of the cannabinoids in the buds to give a higher concentration of THC and or CBD. Here are some different forms of concentrates.

Hash

The oldest form of concentrate, and probably the least potent. Hash is made by collecting the plants resin, or kief and pressing it together. Ice water or ethanol sometimes is used to effectively collect the crystals better to make a higher concentration of the cannabinoids, stripping away the non-desirable materials of the plant.(Source)

Butane Hash Oil (BHO)

Very dangerous way of making concentrate in the fact that butane is highly flammable. (Source) BHO creates a very potent form used for vaporizors or dabbing. The result of heating to extract the cannabinoids leaves a sticky “wax” wax or a solid “shatter” with a high concentration of THC. BHO when tested shows traces of butane and therefore is not the healthiest way to ingest cannabis. (Source)

CO2 Oil

CO2 Vape Juice

The newer, less dangerous, less toxic and best way of preserving terpenes and other healthy flavors and cannabinoids is CO2 extraction. The process is more expensive to get a botanical extractor that uses pressure and carbon dioxide to extract the benefits of the plant into a concentrate. This method is used for vapor pens. (Source)

Rick Simpson Oil (RSO)

A cancer patient in 2003 named Rick Simpson made a concentrate from hemp by soaking the cannabis in naphtha or isopropyl alcohol. The THC and CBD are extracted to make a tar like liquid when the solvent evaporated. RSO, or also known as Phoenix Tears can be applied directly to the skin like a salve. Some companies now produce this concentrate and to have more THC or more CBD.(Source)

Tinctures

Cannabidiol CBD Tincture

Tinctures, were popular before the prohibition of 1937. This method is done soaking the buds, leaves and stems in ethyl alcohol extraction to get the beneficial cannabinoids extracted out. The usual way of administering this is a couple of drops under the tongue.(Source)

Source:

http://www.leafly.com/knowledge-center/cannabis-101/the-great-wide-world-of-cannabis-concentrates

http://www.nbcsandiego.com/news/local/Undercover-Operation-Shattered-Dreams-Busts-Hash-Oil-Labs--275552071.html

http://phoenixtears.ca/articles/solvent-residue-in-the-oil/

http://en.wikipedia.org/wiki/Tincture_of_Cannabis

Benefits of Cannabis for Schizophrenia

Schizophrenia is mental disability where the person has inappropriate thoughts, emotions, behavior feelings and actions causing an altered reality of delusions and hallucinations. (Source) Studies have found a theory that the human endogenous cannabinoid system is a major source of the causes of schizophrenia. (Source) The endogenous cannabinoid system is responsible in the brain to trigger signals relating to appetite, the feeling of pain, mood and memory as well as regulating phychoactive effects by cannabis from the most notable CB1, CB2 and Anandamide receptors of the nervous system (Source).

Studies have shown promising benefits of Marijuana to relieve Schizophrenia symptoms. Cannabis should not be a replacement for prescribed drugs for the condition without talking to your physician. The Drug Enforement Agency DEA has categorized cannabis as a schedule 1 drug, research for cannabis is lacking and conclusive evidence for benefits of Schizophrenia is still in progress.(Source) 

Here are a collection of studies regarding marijuana and Schizophrenia:

Markus Leweke of the University of Cologne in Germany conducted a study with 39 individuals with schizophrenia giving half cannabidiol (CBD) and the other half Amisulpride, an anti psychotic drug used for schizophrenia treatment. Cannabidiol is derived from the cannabis plant and is an antioxidant anti psycho-active part of the marijuana plant. The results showed that the symptoms equally went down for all subjects, with the people using cannabidiol (CBD) having less side effects. (Source)

Dr. Daniele Piomelli, professor of pharmacology at the University of California-Irvine has studied the anandamide receptors of the nervous system in the endogenous cannabinoid system. Dr. Piomellis theorizes with this study that cannabidiol CBD helps with schizophrenia by saying “What CBD seems to be doing is preventing anandamide from being destroyed”.(Source)

Raquel Levin and Fernanda F. Peres in Brazil did a study on mice with schizophrenia in which they gave Cannabidiol CBD to some mice and WIN55212,2 (synthetic cannabinoid agonist) to the other. Both were able to show positive results in improving sensory gating deficits. The results from the team were “Our results reinforce the role of the endocannabinoid system in the sensorimotor gating impairment related to schizophrenia, and point to cannabinoid drugs as potential therapeutic strategies.” (Source)

Future Studies

Currently, GW Pharmaceuticals is doing a study on their own GWP-42003 which is derived from cannabidiol CBD. They are doing the research in hopes of finding treatment with cannabis for schizophrenia. They have finished phase 1 and it shows promising results and they are now doing phase 2 (Source)

For medication to be introduced in the United States with cannabidiol CBD, it first needs to be FDA approved for study. The FDA has approved experimental use for CBD for the treatment of Dravet syndrome. Soon the FDA is set to allow it for clinical trials in showing safety and tolerability for CBD in children.(Source)

Source:

http://clinicaltrials.gov/show/NCT00628290

http://en.wikipedia.org/wiki/Schizophrenia

http://www.ncbi.nlm.nih.gov/pubmed/9130308

http://en.wikipedia.org/wiki/Endocannabinoid_system

http://www.thewire.com/politics/2014/06/its-hard-to-study-marijuanas-medical-benefits-when-its-illegal/373603/

http://healthland.time.com/2012/05/30/marijuana-compound-treats-schizophrenia-with-few-side-effects-clinical-trial/

http://www.leafscience.com/2014/03/18/drug-made-cannabis-treat-schizophrenia/

http://www.ncbi.nlm.nih.gov/pubmed/24567721

http://blog.norml.org/2013/12/16/study-cannabidiol-holds-promise-for-treating-psychosis/

Benefits of Cannabis for Parkinson's Disease

Parkinson's Disease is the disruption of the endocannabinoid receptors in the brain. Nerve cells that produce dopamine are destroyed making the brain to not function in processing messages or muscle function. (Source)

Some studies have shown that the use of Marijuana to relieve Parkinson symptoms can be effective, but physicians warn that it should not be a replacement for prescribed drugs for the condition. Since the Drug Enforement Agency DEA has deemed cannabis as a schedule 1 drug, approval for research into the benefits of cannabis is lacking and conclusive evidence for benefits of Parkinson's is still in progress.(Source) Here are a collection of studies regarding marijuana and Parkinson's Disease:

Movement Disorders Journal with research done by Katerina Venderova in 2004 located in Prague did a study on Parkinson's patients and the results are as follows:

• 45.9% of patients showed mild to major treatment of parkinson's symptoms
• 30.6% showed treatment for rest tremors
• 44.7% showed treatment for bradykinesia ( slowness in movement caused by weakness, tremor or feeling of rigidity).
• 37.7% improvement in muscle rigidity
• 14.1% treatment in L-dopa-induced dyskinesias (disruption in brain signals of movement).
• 4% complained of cannabis worsening symptoms.
• Use of Cannabis for 3 months or more had significant improvement in Parkinson's symptoms

This study was done on less than a 100 patients and the conclusions are that more research needs to be done on a wider population for more concrete findings. (Source)

A theory but not studied enough is that marijuana could benefit Parkinson's Disease since the effects of Parkinson's symptoms are concentrated in the basal ganglia of the brain, which are packed with cannabinoid (THC) receptors that Cannabis main function relates to. (Cb1and Cb2 receptors)(Source)

To ad to the brain function, The British Journal of Pharmacology had a study that showed the following: “Given its antioxidant properties and its ability to activate CB₂ but to block CB₁ receptors, Δ⁹-THCV has a promising pharmacological profile for delaying disease progression in PD and also for ameliorating parkinsonian symptoms.” (Source)

One symptom that Parkinson's Disease has is REM sleep behavior disorder (RBD). The patients studied using Cannabis (CBD) the non psycho-active component of cannabis showed significant improvement. (Source)

OUTCO is San Diego's only legally licensed medical marijuana dispensary offering FREE Delivery and Accepting Debit Cards.

Source:

http://www.parkinson.org/getdoc/6ffea1eb-3439-4e0c-b45e-5da1dc8d7537/default

http://www.ncbi.nlm.nih.gov/pubmed/24845114

http://www.denverrelief.com/blog/conditions-treated-by-cannabis/parkinsons-disease-and-cannabis-marijuana-therapy/

http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2011.01278.x/abstract

http://www.thewire.com/politics/2014/06/its-hard-to-study-marijuanas-medical-benefits-when-its-illegal/373603/

E-Cigarettes and Vape Pens Have Brought Marijuana Into the Light

 

The Origins come from Nicotine

A bong, joint or pipe is a telltale sign of marijuana, and in public that brings a societal frown. A Vape Pen, or originally called an e-cigarette was invented in Beijing China in 2003 by Hon Lik, a pharmacist that had his chain smoking father die of lung cancer, and he too being a smoker of cigarettes. E-cigarettes have had an uphill battle for being accepted as an acceptable method of smoking with many bans of sale in multiple countries, including fines and imprisonment and FDA bans.

Ruyan, Health New Zealand in 2008 did a research study that concluded that for e-cigarettes the toxins and carcinogens are below harmful levels, 100 – 1000x less harmful than smoking tobacco cigarettes. Bans were imposed for the purpose that the liquids formulas had propylene glycol and diethylene glycol, however research showed the 9 toxins in e-cigarettes as opposed to 1000 toxins in a regular cigarette. Non-smoking activists voice concerns that e-cigarettes will be a gateway to the tobacco industry, where as much effort has been put in effect a stop to the popularity of smoking.

Vape Pens in the Marijuana Community

While e-cigarettes are getting flogged in the legislation and headlines, the marijuana community is booming in the vape pen industry. Vape pens are discreet, and are seen in public for they don't advertise what the person is smoking with the absence of fire, smoke and smell. Vape pens use a marijuana concentrate made from the plant which is in the form of a yellow resin liquid. Right now there is not a ban on any state for vape pens, however California is considering a ban on concentrates.

Whoopie Goldberg did an interview for The Cannabist in where she talked about the benefits of the vape pen for medical marijuana. She tells of how easy it is to use for non-smokers and how the amount of “sips” can regulate the amount of drug she needs. She was able to get off of other pain medication and regulate for headache pain from glaucoma in a natural and safe way with cannabis.

Concerns are legitimate as the concentration can be very high, and one inhalation can give someone a mind altering effect. With the ability of the vape pen to be discreet in daily life, a concern for parents and employers may not be able to know if their kids or workers are under the influence.

With the growing popularity of vape pen, the demand for concentrates have gone up and buds or flowers have gone down. The concentrate can be designed for the specific need of the patient for an amount of THC, or for CBD, which is not psycho-active and has antioxidant properties.

OUTCO offers concentrates or vape juice for sale, and is San Diego's only legally licensed medical marijuana dispensary offering FREE Delivery and Accepting Debit Cards.

Source:

http://cannabis/2014/04/17/whoopee-vape-pen-love-story-column/9571/

http://Casanova/E-cigarette_History.html

http://www.npr.org/blogs/health/2014/04/18/302992602/pot-smoke-and-mirrors-vaporizer-pens-hide-marijuana-use

Indica and Sativa, what about Ruderalis?

Cannabis Species

Their are 3 predominant species of cannabis, Indica and Sativa that have been breed over generations to have a high THC content and predictable growing patterns, and Ruderalis, named after the German named “ruderal” meaning weeds by the roadside. Many in the cannabis growing community disregard the Ruderalis species, however it's high content of CBD as well as it's extremely fast growing time may come to be beneficial in the medical marijuana industry.

Ruderalis is thought to come from Sativa, having thin leaves much like the Sativa, but in contrast only growing a foot in height, while the Sativa is the tallest of the cannabis species. The origins are thought to be from Russian cannabis growers where the flowers that escaped outside the plantation seeded and started growing as volunteers. They adapted attributes to survive in the climate such as shorter in length and quicker growing time, losing the attributes that weren't helpful to survival such as high THC content. The ability for the ruderalis to flower without photo-activation makes it unique and necessary for the long days without sunlight in far north climates.

There are reasons to integrate the ruderalis species into the medical marijuana industry:

• Faster Growing time

• Humidity Resistant

• Auto Flowering (light not needed to flower)

• Intense light yields many trichomes leading to high amount of CBD

• Mold Resistant

• Drought Tolerant

Some Popular Cannabis strains have already utilized the Ruderalis species. Neville Schoenmaker, founder of Sensei Seeds, created Ruderalis Indica, Ruderalis Skunk and Four-Way, hybrids that were created in hopes of autoflowering. Sensei Seeds comments that the auto-flowering was not completely successful. Canadian Growers in British Columbia have cultivated the strain Mighty Mite for it's auto-flowering and quick growing, a popular ruderalis hybrid. A hybrid of Mighty Mite but more potent is Guerilla Gold which has a semi auto-flowering uniqueness. FIN-314, also known as Finola, is used for hemp cultivation and has a very low government acceptable THC amount and high in Cannabinoids.

A well known grower named the Joint Doctor took a Mexican Rudy known for it's auto-flowering and mixed it with a Northern Lights and a Williams Wonder to create the Lowryder strain. This popular Lowryder is used by many to create an auto-flowering strain that produces high THC. The auto-flowering is a recessive trait and therefore a consistent behavior of auto-flowering has yet to be achieved.

OUTCO is San Diego's only legally licensed medical marijuana dispensary offering FREE Delivery and Accepting Debit Cards.

Source: http://www.seedsman.com/en/cannabis-ruderalis

The Differences Between Indica and Sativa Cannabis Strains

Differences Between Indica and Sativa

There are many choices to consider when selecting a strain of cannabis, and at OUTCO in San Diego, we have bud specialists to help find a strain for your treatment. One main category for cannabis is separating them into Indica or Sativa, and then hybrids that have the genetics of both. Indica and Sativa have some general differences that are accepted by cannabis connoisseurs:

Indica

• Originated in Higher altitudes

• Higher Yield per plant with shorter growing time

• Shorter and Fuller plants with broad leaves

• Fruity to Skunk Flavors

• Stronger Sedating

Treatment:

• Pain Relief

• Sleep Problems

• Migraines and Headaches

• Stress and Anxiety

Sativa

• Originated close to the equator.

• Less of a Yield and longer growing time

• Grow taller with narrow leaves.

• From Fruity to Cat Piss Flavor

• More uplifting

Treatment:

• Depression

• Increases focus and creativity

• Stimulates and Energizes

• Uplifting and euphoric thoughts

A New Way of Categorizing Cannabis

Jeffrey Taber, who has a Ph.D in Chemistry, was the first to test terepenes in cannabis in 2011. He theorizes that the differences in cannabis are less in whether they are indica or sativa, but more in the different terepenes within the strain of cannabis. Terepenes are like the fingerprint to the plant, rather than the CBD, THC content or name given to the plant that may be found to have been miscategorized. Terepenes are the flavor and taste, but also introduce the multitudes of benefits and effects that vary from one strain to another.

Within each strain their will be different amounts of CBD or THC and also vary on taste and aroma from the different growing conditions. Each strain effects the patient differently depending on body chemistry. The way in which the strain is given to the patient as well will vary the effects, such as vape pen, bong, joint, edible etc.

OUTCO is San Diego's only legally licensed medical marijuana dispensary offering store, free delivery and accepting credit cards.

source: http://www.leafly.com/news/medical/indica-vs-sativa-myth-or-fact

http://www.hightimes.com/read/5-differences-between-sativa-and-indica

http://www.theweedblog.com/the-difference-between-indica-and-sativa-marijuana-plants/