Edibles vs. Smoking

How cannabis is ingested to receive the medicine is subject to each patients preferably. Whether it is smoked or taken orally in an edible has some differences like the time it takes effect, the ability to dose effectively, the duration it lasts, the way it is metabolized, and the difficulty regulating the amount of THC in an edibles ingredients.(Source)

Smoking shows a faster effect than edibles for relief. A study in 2013 looked at the differences of marijuana that was smoked versus the THC pill dronabinol. Smoking showed a relief in symptoms and feeling of it working in 15 minutes, where donabinol showed effect after 60-90 minutes.(Source) Patients suffering from pain tend to prefer faster relief than a prolonged wait period.(Source)

For the extended length of time it takes edibles to take an effect, dosage could be administered too low or too high. A faster effect from smoking could allow patients to give the correct amount from feeling the effects quickly. Patients during a study reported that while smoking gave fast effects, the psycho-active high usually lasted longer than the relief of pain. The study also showed most patients felt more high when smoking rather than using the edible.(Source) On the flip side with a delayed effect on edibles, an overdose can occur and make patients uncomfortable. The effects of the overdose can be agitation, anxiety or hallucinations.(Source)

The duration of smoked cannabis can last a couple hours where edibles once they take effect can last 3-4 hours. With pain sufferers a faster effect is desired, however a longer duration is desired as well. For some patients finding a time and a place to smoke every couple of hours can be unfeasible, making it more convenient for a longer lasting effect to be preferable. (Source) 

Dr. Sanjay Gupta, who is a neurosurgeon and CNN’s chief medical correspondent weighed in on the subject and said that he would argue that vaporizers are the best way to deliver marijuana by activating it without burning it. Edibles, Dr. Gupta went further to say, can lead to uneven absorption which can lead to undesired effects. (source)

The way edibles are metabolized can effect the way THC is absorbed unevenly. Kari Franson, PharmD, PhD, Clinical Pharmacologist and Associate Dean for Professional Education, Department of Clinical Pharmacy, at University of Colorado Skaggs School of Pharmacy studied the metabolism of THC. “The THC will compete for metabolism in the liver with other drugs. Things that are inhaled can go directly to the brain and not have these interactions. So even confident users can get surprised with an edible.”

Kari Franson also warns about the unregulated standardization of edibles. The package may say in contains a certain amount of THC, but not be correct. Laboratory tests of the products can register the THC higher or lower in concentration, not making for a consistent way to administer the medicine properly.(Source)

Source:

http://www.leafscience.com/2014/03/13/dr-sanjay-gupta-talks-marijuana-vaporizers-vs-edibles/

http://www.leafscience.com/2014/01/19/marijuana-pill-patients-might-better-smoking/

http://www.ppcswfl.com/articles/Dr.%20Auld%20-%20Medical%20Marijuana%2012-31-13.pdf

http://www.webmd.com/pain-management/news/20130422/using-marijuana-to-treat-pain-a-pill-may-outlast-a-puff?

http://www.forbes.com/sites/alicegwalton/2014/06/04/is-eating-marijuana-really-riskier-than-smoking-it/

http://www.cpr.org/news/story/denver-emergency-room-doctor-seeing-more-patients-marijuana-edibles

Shop Small at OUTCO Today

 

Because of our local loyal customers, OUTCO is a leader in dispensing legal and quality cannabis in San Diego County. We are the only legally licensed medical marijuana dispensary in the entire county. OUTCO is locally owned, and we contribute to the San Diego economy through taxes and our growing employee base.. 

But despite our stature, our customer base knows that when they come to OUTCO, they are not only working with the most reputable and safest establishment in this industry, they are receiving the kind of service that only a SMALL company can provide.  So whether you stop by or order on line, SHOP SMALL on Saturday November 29th and receive:

• Extraordinary expertise and personal attention
• Excellent selection of Brands and Strains that customers know and trust.

• Free Delivery under $40 to ALL of San Diego

• Ability to process Debit Cards

Call 619.448.4420 to order and become a member for free.

Legalizing Marijuana Reduces Crime

The use of marijuana has shown a two fold effect on the rate of crime. The first being the act of legalizing allows drug possession charges to go down dramatically. The other showing that the effect of the drug shows less tendency to commit violent crimes.

Colorado is almost one year into legalization of recreational use of marijuana. Millions of dollars have been saved by removing criminal penalties to possession of marijuana. Arrests for the possession of marijuana before legalization were upwards of 10,000 arrests a year.(Source) Colorado Center on Law & Policy projects a reduction in $12 million a year on criminal costs by legalizing marijuana. (Source) With the state tax excised on sales and other factors for legalization it is proposed to save upwards of $60 million for the state of Colorado. (Source)

A Study done in 2010 researched the crime rates after legalization of marijuana. They found that drug and property theft went up, while violent crime went down. Rates for aggravated assault, robbery and homicide show a large reduction in areas that legalize medical marijuana.(Source) In 2010 a study was conducted to see if marijuana users were repeat criminal offenders. The bulk of crime with the population was related to illegal possession and distribution of marijuana, not with any other crimes. By legalizing marijuana these crimes would cease to exist. (Source)

Dispensaries are a common target for theft and crime, in where they dispense large amounts of cannabis and manage sales in cash. Dispensaries because of the threat of theft implement security guards and camera surveillance which in turn has shown to reduce crime in the immediate vicinity of the dispensaries. (Source) The presence of dispensaries has not shown any increase in property theft or violent crime in the community. (Source)

Source:

http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0092816

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683594/

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2950879/

http://www.ncbi.nlm.nih.gov/pubmed/19839964

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364319/

http://cclponline.org/wp-content/uploads/2013/11/amendment_64_analysis_final.pdf

http://marijuana-arrests.com/210,000-Marijuana-Arrests-In-Colorado.html

Pilgrims, Indians and Cannabis

Cannabis came over to the Americas first to South and Central America by the Spanish and Portuguese. The first cannabis reported in North America was in 1606 by a Herbert, a French agriculturist that brought it to the Canadian colonies of what is now Nova Scotia.

King James the First gave a proclamation to the pilgrims in Jamestown Colony in 1611 to grow hemp. No record shows that Pilgrims brought cannabis over on the Mayflower. Most pilgrims originated from England and Holland where hemp in these Old World areas were well known for cultivating “state of the art” botanicals in the sixteen hundreds. Cannabis was part of early colonial New England life used for barter and fiber for many materials.(Source)

The Native American indians did not smoke cannabis in their peace pipes. The common smoking of choice was tobacco or kinnikinnick. Kinnikinnick was a mix of various leaves, mostly the bearberry leaves, being prevalent as much as 1000 years before tobacco was introduced to the Native Americans. Tobacco was believed by the Native Americans to float up to the Great Spirit carrying oaths and prayers. Cannabis for smoking was introduced in North America in the early 1900's when the Mexicans migrated north.(Source)

Source:

http://the420times.com/2010/01/history-of-medical-marijuana-cannabis-in-the-north-american-colonies/

http://www.jstor.org/discover/10.2307/481405?uid=3739256&uid=2&uid=4&sid=21104642388741

The Benefits of Cannabis with Crohn's Disease

Crohn's Disease is a re-occurring inflammation of the gastrointestinal tract as well as an inflammatory Bowel Disease (IBD). Not to be confused with another IBD disease, ulcerative colitis, Crohn's affects any part of the gastrointestinal (GI) tract rather than only the colon or large intestine. Genetics, heredity and/or environmental factors have been shown to lead to Crohn's disease.  This disease affects around 700,000 Americans mostly of European descent. Symptoms of the disease are loss of appetite, weight loss, fatigue, night sweats, irregular menstrual cycle and fever. Inflammation of the GI Tract can also lead to diarrhea, bleeding, cramps, pain and constipation. (Source)

The enteric nervous system helps aid in gut function while the endocannabinoid system (ECS) helps to maintain gut motility, inflammation and sensation. Both systems contain Cannabinoid receptors CB1 and CB2 receptors making medical marijuana use a viable treat for Crohn's disease patients . (Source)

A pilot study of 32 patients of Crohn's disease was conducted at the International Association for Cannabis as Medicine conference at Leiden University in the Netherlands by Physicians in the Society of Cannabis Clinicians. Patients in this study showed  improvement in symptoms of vomiting, depression, nausea, gut pain, appetite, activity, fatigue, flareups and severity of flareups.(Source)

A study was completed at the University of Calgary in 2009 of 313 people with Inflammatory Bowel Disease (IBD).  The results of this study reported improvement of  abdominal pain, cramping, diarrhea, and joint paint in which 17.6% of the patients used cannabis using the inhalation method. (Source)

A study in 2011 with 30 Crohn's Disease patients showed that 21 reported improvements in all symptoms.(Source) in 2013, 21 patients involved in  a study smoking 2 marijuana cigarettes a day. showed improvement in sleep and appetite.  These patients with Crohn's disease were subjects that had not responded to other treatments(Source)

In a questionnaire given at a clinic with 191 Crohn's disease patients, 48% reported use of cannabis to reduce symptoms such as abdominal pain diarrhea and appetite were what the patients. Patients in the group that had abdominal surgery were more likely to use cannabis for treatment. (Source)

Source:

http://www.ccfa.org/what-are-crohns-and-colitis/what-is-crohns-disease/

http://www.medicaljane.com/2014/06/28/medical-marijuana-and-inflammatory-bowel-disease-ibd/#

http://www.beyondthc.com/wp-content/uploads/2012/07/Crohns05.pdf

http://www.ima.org.il/imaj/ViewArticle.aspx?aId=375

http://www.sciencedirect.com/science/article/pii/S1542356513006046

http://journals.lww.com/ibdjournal/Abstract/2014/03000/Cannabis_Use_Provides_Symptom_Relief_in_Patients.6.aspx

The Benefits of Cannabis for Autism

Reports have shown that cannabis can help treat symptoms of autism. Autism is a disorder in brain development that affects social interaction, verbal and non-verbal communication and signs of repetitive behaviors. Autism has a broad spectrum of symptoms and sources in the body for the resulting behavior.(Source) Five percent of autism cases have also an occurrence of Fragile X Syndrome.

Fragile X Syndrome occurs when the X chromosome has a failure to express the fragile X mental retardation protein or FMRP. There are varying degrees of severity to how bad the mutation is. Symptoms include attention deficit, hyperactivity, anxiety and aggression.(Source)

Studies show that the Fragile X Syndrome affects the part of the body known as the endocannabinoid system. Cannabis affects the endocannabinoid system in the body which is made up of lipids and receptors.  The function of these receptors is to process appetite, feelings of pain, mood as well as memory functions. One of these lipids is 2-AG or 2-arachidonoylglycerol, which is crucial for cell function and communication. People with fragile X syndrome have a non-functioning 2-AG lipid. This lipid is found as a non psycho-active cannabinoid found in cannabis. Studies showing this correlation help explain why these symptoms are reduced when marijuana use replace this non functioning 2-AG in the body. (Source)

Researchers at Stanford University studied mice in which two synapse-adhesion proteins led to a block or slowing of signaling in their brains. This study reflects another form of the spectrum of autism in which there are mutations in neurologin-3 (NL-3) and R451. This study showed that the CB1 receptors  which are affected by these mutations can be helped through targeting of this receptor through use of marijuana treatment.(Source)

The researchers studied mutations in neurologin-3 (NL-3) and R451. . The mutation of neurologin-3 (NL-3), a gene encoding a protein that builds and maintains synapses, demonstrated a deletion of the entire gene.  In contrast the mutation of R451, demonstrated a single amino acid substitution. Both of these mutations have shown to be associated with autism in humans. (Source)

Success Stories

A family in San Diego wrote about their adopted son Sam that who showed signs of autism at 18 months old. The family gave doses of marijuana to their son at age 8 and documented changes in his behavior through a daily journal  read here). Their observations showed behaviors of agitation and aggression diminished leaving their son with a calm focused attention which was previously unobserved in his daily behavior.

Alex Echols, a resident of Oregon, suffers from a form of autism called tuberous sclerosis.  This form of autism has been shown to cause non-malignant tumors in organs. These tumors have affected his brain functions  to the point where he experiences powerful seizures and engages in self- inflicted harm. After trying many different drugs with Alex to no avail his parents decided to give him cannabis.   This resulted in a major reduction in self inflicted harm and a an increased relaxation in use of his hands for exploration. (Source)

Source:

http://www.autismspeaks.org/what-autism

https://decryptedmatrix.com/live/marijuana-cannabinoids-found-to-help-combat-autism/

http://www.nature.com/ncomms/journal/v3/n9/full/ncomms2045.html?WT.ec_id=NCOMMS-20120925

http://www.letfreedomgrow.com/cmu/SamsStory.htm

http://www.autismdailynewscast.com/studies-finds-link-between-autism-and-cannabinoids/921/laurel-joss/

Cannabis Strains that are High in CBD

Most cannabis strains on the market are bred for their cannabinoid potency in THC, which is the active part that give a psycho effect. There are 85 active cannabinoids that are known in cannabis and cannabidiol or CBD is growing in popularity for it's high effectiveness for medicinal use without the psycho-active properties.

Treatment with Cannabidiol CBD

Cannabidiol in marijuana is the second most prevalent cannabinoid behind THC. At first it was thought the only benefit of CBD was to counteract the stoned effect that THC gives. However, CBD has been shown in research to give anti-inflammatory, analgesic and lower anxiety without the psycho-active effects that THC gives. These benefits have shown promising results for treatment in crohn's disease, PTSD, multiple sclerosis and a form of epilepsy called Dravet's Syndrome. Strains high in THC are usually at levels of 20% above, where CBD over 4% are known to be in high concentration. The FDA is approving a study this year to look at the effectiveness of CBD in children to hopefully make this a more accessible treatment.(Source)

Many patients are vocal about the importance of THC with CBD for complete effectiveness as a treatment. The government has acquired a patent for the benefits in THC, and research has showed it to help with appetite loss, nausea, multiple sclerosis and pain. Allowing to manage the percentage amount of THC and CBD gives the most effectiveness as well as also having control of how it is consumed. (Source)

Strains that are High in CBD

   The strains listed give different concentrations of CBD to THC ratios and also differentiate with their terpene properties to give different medicinal effects.

AC/DC - Sativa dominant 1:20 ratio of THC:CBD, a phenotype of Cannatonic

Cannatonic – Hybrid with 1:1 ratio. Origins are MK Ultra X and G-13 Haze.

Canna Sue – 13.8%CBD to 10.4%THC from Southern Humbolt Seed Company cross of Canna Tonic and Sour Tsunami

Charlotte's Web – Sativa dominant created by the Stanley brothers

Harlequin – Sativa Hybrid, registered 11.6%CBD to 8.4%THC (Source)

Harle Sue – Sativa Hybrid, registered 9.4%CBD to 6.7%THC, cross of Harlequin and Sour Tsunami

Jamaican Lion – Sativa with 1:1 ratio or better, cross between Mountain Lion and Yarders.(Source)

Omrita Rx – Indica dominant, 9.5% CBD to 11% THC, lots of leaves to juice, High in Beta Caryophylline.

Oracle* found to be identicle to AC/DC

Sour Tsunami – Sativa hybrid with 7.24%CBD to 4.32%THC ratio from Humboldt Seed Company

Women's Collective Stinky Purple

Swiss Gold – Sativa hybrid 7.2%CBD and 3.6%THC

Valentine X – Hybrid known to be highest CBD ratio 25:1, a phenotype of AC/DC

(Source)(Source)

Source:

http://www.projectcbd.org/medicine/strain-library/

http://www.leafly.com/news/lifestyle/whats-the-deal-with-these-high-cbd-strains

http://www.mpp.org/assets/documents/low-or-no-thc-high-cbd.html

http://synergycbd.com/cdb-rich-strains/

http://www.hydrocanna.com/showthread.php?t=9683

Brotherhood of Eternal Love

At Outliers, we believe it is important to consider the history of our industry and recognize those individuals and groups who paved the way toward this credible treatment path. From the 1960's to the late 70's the Brotherhood of Eternal Love operated in Orange County California. Also known as the Hippie Mafia, they used, acquired and sold drugs. John Griggs originally started the group as a commune and by 1969 it had evolved into a group that made LSD and imported hashish.(Source)

The founders of the group started at the influence of Timothy Leary's book's and comments to “Turn on, tune in, drop out.” The group, first calling the members “the disciples” and organizing a non-profit religious group that believed that LSD\acid could be useful as a treatment for other addictions and there violent behavior and put them in an utopia state. (Source) They eventually set up a headshop in downtown Laguna beach 670 S. Pacific Coast Highway across from the Taco Bell that still stands their today called the Mystic Arts World. (Source)

The founders set up their “church” as a commune in a mountain town East of Orange County called Idyllwild in Modjeska Canyon. Their they wanted to tune out the world, aspire to have Timothy Leary be their leader and enjoy the exit from society. With the publicity of their organization, many people were afraid to visit in fear of incarceration. Also many members of the Brotherhood were smugglers and didn't attain for the solitude life, but instead more for the entrepreneurial aspect of the money made. (Source)

Some notable groups and people benefited from the Brotherhood of Eternal Love. Howard Mark's, or Mr. Nice smuggled for the group. In the late 60's the famous blond surfer from The Endless Summer, Mike Hynson, began to smuggle hashish from India back to Southern California by storing it in hollowed out surfboards.(Source)

In 1970 many people of the hippie movement were going to the Hawaiian island of Maui, and so did the Brotherhood of Eternal love. Loaded with a 1500 Kilos of Mexican weed, the Aafje Schooner was bought, loaded and put through the Panama Canal and then made it's way to Maui. This weed was the origination of the popular cannabis strain Maui Wowie.(Source) Hollowed surfboards packed with Maui Wowie made it's way back to the mainland.

On Christmas Day in 1970, a show was organized in Laguna Beach called “Laguna Beach on Acid” had an airplane dropped thousand of advertisements with a dose of Orange Sunshine LSD. At the time they were the nation's largest narcotics network. The proceeds of sales ended up funding to help Timothy Leary who had escaped from a jail in central California to help him flee to Kabul Afghanistan. (Source)

The Brotherhood of Eternal Love started to break down on August 5^th, 1972 when raids in California, Oregon, and Maui, Afghanistan arrested 45 members. All being released a couple months later the group went underground or abroad. The last arrest was in 2009, and a book was published in 2010 by Nicholas Schou and a documentary called Orange Sunshine is out on Youtube. (Source)

In a speech by Nicholas Schou on youtube, he interviewed a member that said that his theory of that cocaine ended the brotherhood. The love and spirituality in this members opinion was ruined with the destruction of that vibe with cocaine and the desire to make money for drugs. (Source)

Source:

http://en.wikipedia.org/wiki/Brotherhood_of_Eternal_Love

http://lagunabeachmagazine.com/the-happening/

Nicholas Schou in Orange Sunshine Documentary

http://www.ocweekly.com/2005-07-07/features/lords-of-acid/

http://belhistory.weebly.com/bel-files.html

http://belhistory.weebly.com/

Cannabis and the Type 1 Vanilloid Receptor

TRPV1 also known as Type 1 Vanilloid Receptor, Capsaicin Receptor and transient receptor potential cation channel subfamily V member1 is a protein that the TRPV1 gene encodes. This receptor regulates body temperature and the sensation of heat and pain. Found in the nervous system it is a communicator of pain to the brain, and desensitizing gives a analgesic pain free feeling.

Cannabinoids found in marijuana have been found to be an antagonist to the TRPV1 receptor, which can help with neurpathic pain, multiple sclerosis, chemotherapy, amputation as well as osteoarthritis, anxiety and long term depression.(Source) Cannabidiol CBD has shown to have an activation of the TRPV1 receptors. (Source) Endocannabinoid anandamide that is affected by the use of cannabis has been shown to act on the TRPV1 receptors as well. (Source) Dopamine which is increased with cannabis use also effects the TRPV1 receptor.(Source)

Along with treatment in symptoms, cannabis can reduce cancer to it's role in the TRPV1 receptor. Neuroblastoma is a cancer started in the nervous system in the human fetus or embryo that resides in the nervous system. This form of cancer is usually seen in young children before the age of 10. Research has shown that cannabis can delay or stop the cancer cell growth of neuroblastoma by activating the TRPV1 receptors. (Source)

Source:

http://jpet.aspetjournals.org/content/318/3/1375

http://en.wikipedia.org/wiki/TRPV1

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC123079/

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1574087/

http://www.ncbi.nlm.nih.gov/pubmed/17442052

Different Cancers that Have Been Shown to be Reduced with Cannabis

Tumors in the brain have shown promising results to reduce or be destroyed through many research studies using marijuana. The inhibiting of cancer cells to proliferate do not stop with tumors in the brain. Studies have shows that there are promising results for many other cancer cells. Here is a list and studies on how cannabis-based medicine.

• Biliary Tract Cancer (cholangiocarcinoma)(Source)
• Breast Carcinoma – By inhibiting anandamide(Source)
• Cervical Carcinoma – By increase of inhibiting tissue of Matrix Metalloproteinases-1 (MMP-1)
(Source)
• Colorectal Carcinoma - Cyclooxygenase 2 (COX-2) found in most colorectal cancer cells were reduced by the increase in anandamide, which increases with cannabis use.(Source)
• Leukemia Cells – THC induces Leukemia cell death. (Source)
• Lymphoma – used with other drugs to induce lymphoma cell death (Source)
• Lung Carcinoma – THC induced Lung Cancer cell death. (Source)
• Neuroblastoma – Type 1 Vanilloid Receptor (Source)
• Oral Cancer – By inhibiting O(2) in Oral Cancer cells to cause death to cells (Source)
• Pancreatic Adenocarcinoma – By increasing ceramides and affecting the CB2 receptors (Source)
• Prostate Carcinoma – By increasing ceramides and effects on anandamide (Source)
• Skin Carcinoma – By activating the CB1 and CB2 receptors (Source)
• Thyroid Epithelioma – CB1 Receptors (Source)

• Uterus Carcinoma - Cell Growth Inhibition (Source)

Cannabis Reduces Brain Tumors

Cannabinoids found in marijuana have shown to inhibit tumor cell growth. This is achieved in how they effect signaling pathways in the brain. Treatment with cannabis has been found to be cheaper to produce and have less side effects and toxicity to other conventional chemo therapies and drugs, encouraging further research to make it a mainstream medicine.(Source)

In 1998 it was first recorded that delta-9-THC promoted cell death in glioma (brain tumor) cells in cultures.(Source) In 2000 a study was done with THC as well as WIN 55,212-2 which is a chemical that shows effects similar to cannabinoids, with a completley different chemical structure. Both increased ceramides which inhibited cancer cell growth.(Source) Ceramides are fatty acids that tumor cells seem to invite in. Ceramides communicate with the lysosomes in the cells to tell them to burst, killing the cancer cell. Ceramides are also important in hair and skin acting as a protective shield against the environment.(Source)

A study in 2003 found that THC in laboratory tests create cell destruction in cells by modifying the signal pathways inside the tumor, allowing it to disrupt growth or kill the tumor. (Source) With much discussion about THC benefiting tumor cell death, research also concluded that the cannabinoid CBD also showed equally promising results in tumor cell death without the psycho active properties. (Source)

In 2004 it was found that cannabinoids reduce tumor growth by affecting the vascular endothelial growth factor, VEGF, or the function of giving blood supply to tissue when circulation is inadequate. The blocking of the pathway to blood flow of tumors showed a reduction in the tumor cells. (Source)

In 2005 a study found that THC did a better job of only inhibiting the growth of tumor cells as opposed to healthy cells more effectively than the chemical medicine WIN 55,212-2. (Source)

Professor Guzman who conducted a lot of these research studies found in 2006 that patients with reoccuring glioblastoma multiforme showed a reduction in tumors. (Source) In 2010 it was found in research that a widely used chemotherapy drug used to treat brain tumors called temozolomide (TMZ) increased effectiveness when administered with THC. (Source) A report was published in 2011 in which two children using cannabis to treat cerebellar and optic pathway tumors by inhibiting the growth effectively.(Source)

In 2014 glioma, an aggressive and hard to treat cancer in the brain was treated with CBD and THC along with radiotherapy. Results found that the combination of the cannabinoids found in marijuana improved the radiotherapy by prepping the glioma cells to receive the ionizing radiation more effectively and reducing the tumor cells.(Source)

Source:

http://www.nature.com/nrc/journal/v3/n10/abs/nrc1188.html

http://mct.aacrjournals.org/content/early/2014/11/12/1535-7163.MCT-14-0402.abstract

http://norml.org/library/item/gliomascancer

http://molpharm.aspetjournals.org/content/54/5/834.short

http://www.sharecare.com/health/cancer-treatment/how-ceramides-help-fight-cancer

http://jpet.aspetjournals.org/content/308/3/838.full

http://mct.aacrjournals.org/content/10/1/90.abstract

http://www.ncbi.nlm.nih.gov/pubmed/21336992

Cannabis Has a Good Reputation by Many

Reports are showing up that make it clear that medical marijuana has a good reputation. And the results of the elections in the United States reflect this, but also the research studies. The 2014 Gallop poll shows that more people are in favor of legalizing marijuana in the country. (Source)

A study was done in California in 2012 of the medical use of marijuana and it's benefits. About 5% of the adult population stated that they had used marijuana and 92% believed that it helped to treat medical conditions. Placebo's generally show a 30% of benefits, so the fact that it was overwhelmingly positive results shows a need and a benefit for medical marijuana in the community. Gender, education, age, ethnic and region showed consistent findings and the prevalence across all demographics. (Source)

A Survey was conducted by the New England Journal of Medicine in which 1,446 doctors form 72 countries and 56 states and provinces in North America commented on whether they would recommend medical marijuana for treatment. Seventy – Six percent of the voters approved marijuana for medical use in North America, 78% in Europe and Latin America. (Source)

In 2014 WebMD did a survey of 1,544 doctors the issue of legalizing medical marijuana for benefits to patients. The Doctors were from 12 specialties from 48 states that found 69% agreed that cannabis can help with treatment for medical conditions. (Source)

A Fox News Poll showed in 2013 that 85% of the votes were in favor nationwide for medical marijuana. 1,010 of the voters agreed that medical marijuana prescribed by a physician should be legal, which is more than 3 out of every 4 americans. (Source)

An NBC News/ Wall Street Journal Poll results showed that most americans believed that alcohol, sugar and tobacco are more unhealthy than consuming marijuana. Tobacco was the highest preceived threat to health of 49% followed by alcohol at 24%, sugar at 15% and lastly marijuana at only 8%. (Source)

Source:

http://www.gallup.com/poll/179195/majority-continues-support-pot-legalization.aspx

http://www.ncbi.nlm.nih.gov/pubmed/25255903

http://www.nejm.org/doi/full/10.1056/NEJMclde1305159

http://www.webmd.com/news/breaking-news/marijuana-on-main-street/20140225/webmd-marijuana-survey-web

http://online.wsj.com/public/resources/documents/WSJNBCpoll03052014.pdf

The History of Kush Cannabis Strains

Kush Strains

The popular kush strains originate from the fertile mountains and valleys of the Hindu Kush Mountains in Afghanistan and Pakistan. Part of the Himalayan mountains, this region for centuries has cultivated indica dominant cannabis, some of the worlds finest plants. The 1960's and 70's brought travelers from far and wide to bring back seeds, including the members of the Brotherhood of Eternal Love, based in Southern California. In 1973 Afghanistan made the sale of hashish illegal.

The shorter times of the indica genetics allowed from shortened flowering times helping people to grow further north and grow their own. Kush is known for it's citrus flavor with a skunk odor, a high potent couch lock effect that lasts long, great for nighttime.(Source) Terpenes which are the flavor and smells that attribute to the cannabis also add to how the medicinal values take effect. Kush varieties have varied terpenes, showing that the hybrid pairing makes them all different and unique. Here are some popular Kush Strains that Outliers Collective have had in inventory and our patients have enjoyed:

BubbaKush

BTYOG Kush

Yoda OG

Brute OG

Fire OG

San Fernando Valley OG Kush

Sweet OG

Tahoe OG

Banana OG

Chem 4 OG

Lemon OG

White Fire OG

Source:

http://www.hightimes.com/read/story-kush

Banana OG

Banana OG

Banana OG has an old banana smell, and is cross between OG Kush and the strain Banana. Patients describe it as helping to increase appetite, muscle pain, pain relief, anxiety, panic attacks, depression, and sleep. With a high THC percentage, it comes on slower than most so it can be deceiving. As an all indica strain it also known for it's high CBD content.

OUTCO.com offers a variety of strains, contact us today for more information on ordering.

Source

http://www.medicaljane.com/review/banana-og-smells-like-old-banana-peels-christmas/#

Fire OG

Fire OG

Created from OG Kush and San Fernando Valley OG Kush F3, Fire OG by “Raskals OG Kush”. FireOG is known for it's red hairs which gave it's name. A very potent strain, it has a white frostiness that can give up to 20% THC and over .35% CBD. Popular in the early 2000 LA marijuana culture, Fire OG has a pine diesel scent that gives a sativa intense euphoria, while still giving a indica dominant soothing relaxation effect.

Some regard the Fire OG as one of the most potent strains available. Patients describe it as helping to treat anxiety, depression, increased appetite, panic attacks and pain relief. The name matches the effect allowing for up to a three hour effect.

OUTCO.com offers a variety of strains, contact us today for more information on ordering.

Source:

http://www.leafly.com/hybrid/fire-og

http://91life.stickyguide.com/marijuana-reviews/flowers/fire-og-medithrive

http://www.cannabissearch.com/strains/fire-og-kush/

San Fernando Valley OG Kush

San Fernando Valley OG Kush

San Fernando Valley OG Kush, is also known as SFV OG Kush. The origins of the Kush is Chemdawg crossed with Lemon Thai and Hindu Kush made by Cali Connection. A pine, lemon and diesel taste with a high THC and CBD percentage, it is a favorite with many patients. The strain is well balanced for a sativa like euphoria with a relaxing indica effect. Many like the strain for being able to use midday without making you too drowsy and unable to concentrate. It is also a good nightime strain though to allow you to relax without putting you to bed. Patients describe SFV OG Kush for treatment with anxiety, arthritis, depression, stress and headaches.

OUTCO.com offers a variety of strains, contact us today for more information on ordering.

Source:

http://blog.sfgate.com/smellthetruth/2014/08/13/san-fernando-valley-og-marijuana-s/

Tahoe OG

Tahoe OG

A cross between OG Kush and SFV OG this strain is known as one of the strongest bred by the Cali Connection. Tahoe OG gives a positive feeling of euphoria is quickly goes to a heavy effect that gives a happy feeling. Patients describe it as helping appetite, creativity, pain, and insomnia. Many describe it as giving a goofy happy feeling that is good for after work. Tahoe OG won 3rd place Indica Cup at the 2011 Cannabis Cup.

OUTCO.com offers a variety of strains, contact us today for more information on ordering.

Source

http://www.thecannabist.co/2014/02/14/tahoe-og-marijuana-review-uplifting-contemplative-but-anxiety-under-pressure/4656/

http://www.medicalmarijuanastrains.com/tahoe-og-kush/

Chem 4 OG

Chem 4 OG

Cali Connection crossed Chemdawg 4 with San Fernando Valley OG which is indica dominant to create Chem 4 OG. This hybrid has a good balance with a head high that hits fast followed with a full body relaxation. Chem 4 OG has a pine, earth and lemon scent and taste. Patients describe it as helping with pain, insomnia, multiple sclerosis and anxiety.

Cali Connection describes the strain origination:

 "The Chem 4 clone was found from seeds started in 2006 from the original seed stock chemdog sent joebrand. joebrand stated the seeds chem sent him and out of them there was chem 1,2,3,4. the Chem 4 is what joebrand dubbed the Reunion pheno as it reminded him most of the original dogweed from crested butte. i crossed this to my SFV OGK F4 male in hope of bumping up the yield on the og, and in hopes of bringing a little more citrus out of the chem4. Expect large yields form this hybrid." 

OUTCO.com offers a variety of strains, contact us today for more information on ordering. 

Source:

http://www.cannabissearch.com/strains/chem4-og/

http://www.seedsman.com/en/chem-4-og-regular-seeds

White Fire OG, also WIFI OG

White Fire OG

A 2010 and 2014 Cannabis Cup Champion, the White Fire OG is a hybrid from Karma Genetics. The strain is a cross between Fire SFV OG Kush and the Krome's The White. It is also known as WIFI OG. Known for it's high potency and lively taste, the Krome's The White addition adds a muted and musky taste. The flavor tastes much like the aroma with OG flavor of pine and lemon with a smoky musky aftertaste that lingers. Depending on the particular variation it will be Fire OG dominant will be more slending and pointed leaf structure while White dominant will be more white in the trichomes with a stout bud appearance. Regarded as the highest potency of OG strains, makes a head rush and heavy limbs with up to 20% THC potency that offer social and happy while in higher doses could be for relaxation. Patients describe it as treating stress, depression, pain relief with increased appetite and relaxation.

OUTCO.com offers a variety of strains, contact us today for more information on ordering.

Lemon OG

Lemon OG

LemonOG is a hybrid of Las Vegas cut of Lemon Skunk with OG Kush made from the world renowned seed company DNA Genetics based in Amsterdam. It has a mild lemony citrus with a earthy taste with a pleasant fruity smell with a skunk undertone. With fluffy buds that are not tight, it gives a quick heavy feeling of being happy and relaxed while initiating appetite.  Patients describe it as helping to relieve stress and relax, focus, relieve pain and migraines while increasing appetite.

OUTCO.com offers a variety of strains, contact us today for more information on ordering.

Brute OG

Brute OG

An indica with a strong citrus & pine scent, Brute OG gets it's name with it's fast acting brute force. Very fast acting and strong, it is a good strain to use at the end of the day. Patients describe Brute OG to treat severe pain, muscle tension and insomnia. Brute has tight and dense bud with yellow orange hairs and sticky white crystals. The origins of the Brute OG is described as a cross between Private Reserve and Skywalker OG.

OUTCO.com offers a variety of strains, contact us today for more information on ordering. 

Source:

http://dispensaryindex.com/archives/1508

Holy Grail Strain

Holy Grail Strain

Holy Grail OG

An Indica dominant strain, the Holy Grail OG was created by DNA Genetics and Reserva Privada Colorado. With a spicy and citrus kush smell and taste, it is known for it's large and dense buds. High THC concentration but known for a mellow relaxation, patients describe it as helping with creativity and a euphoric feeling to help with stress, pain, depression, insomnia and appetite. 

OUTCO.com offers a variety of strains, contact us today for more information on ordering. 

Source:

http://www.leafly.com/hybrid/holy-grail-kush

The Benefits of Cannabis for Epilepsy

Cannabis with a high content of Cannabidiol CBD have been found to help treat epilepsy in some patients. A certain type of epilepsy, called Dravet Syndrome has shown the most promising treatment with marijuana than other types of epilepsy. Most treatment is administered with a cannabis oil from the Charlotte's Web Strain made by a non-profit organization Realm of Caring(Source), however much of the CBD rich cannabis administered gives similar treatment and different concentrations of CBD, THC and THCA are needed for a more precise treatment for the patient. Legislation and regulation of the medicine is targeting a CBD only medicine, but many believe it is the whole plant that offer the effects, not just the CBD cannabinoid.(Source)

Here is a compiled list of studies that show the benefits of Cannabis with Epilepsy:

September 2003 - The Journal of Pharmacology and Experimental Therapeutics - The Endogenous Cannabinoid System Regulates Seizure Frequency and Duration in a Model of Temporal Lobe Epilepsy
This study showed in rats that had epileptic seizures to be reduces or terminated with THC and CBD from the effect that the cannabinoids had on the CB1 Receptors.

March 2004 – US National Library of Medicine - Endocannabinoid Effects on Febrile Seizures: Not Just a Toke(n) Mechanism
This study showed that in rats a febrile seizure lasting up to 22 minutes was regulated or terminated with cannabis from it's ability to inhibit GABA, a form of neurotransmitters, which also shows that the result of seizures relies in the increase of GABA being released.

May 2004 – US National Library of Medicine - Cannabinoids: Defending the Epileptic Brain
Another study showing the benefits of Cannabis affecting mice in the CB1 receptors, using both the THC and CBD.

June 2004 – Neurology.org - Marijuana use and epilepsy
This is a telephone survey, calling people with epilepsy and finding if they have used marijuana treatment and their findings. 24% of patients called felt that marijuana was an effective treatment for their epilepsy.

November 2004 – ScienceDirect.com - On-demand activation of the endocannabinoid system in the control of neuronal excitability and epileptiform seizures
This study formulates a theory that certain types of seizures can be surpressed or increased with the cannabinoid system and how it regulates the GABA can help regulate the endocannabinoid system.

January 2006 – US National Library of Medicine - Endocannabinoids: A Critical Regulator of Activity in the Developing Brain
 Study showing that the theory that during pregnancy the interferance with marijuana to inhibit CB1 activity or an obesity drug that increases CB1 activity can disrupt the developing endocannabinoid system.

Marijuana and Epilepsy – page on Neuro Science Fundamentals This article talks about Charlotte Figi's story and the introduction of the Charlotte's Web strain to help treat epilepsy.
Edward Maa M.D, an assistant professor at the University of Colorado Department of Neurology,is conducting a study at University of Colorado Anshutz Medical Campus on epilepsy research. The study will separate epilepsy sufferers in two groups of whether the Charlotte's Web strain reduces the epilepsy symptoms by 50% and another group that the symptoms are not helped by the cannabis strain. He will do genetic analysis to find out what the differences in the epilepsy is to help target the marijuana to the correct patients.(Source)

On July 28^th, 2014 The Realm of Caring released the Charlotte's Web Medical Hemp Act of 2014 to legalize federally the CBD only oil for epilepsy. Many believe this is not a complete effort for treatment, Edward Maa is at the forefront in writing articles on how important it is for the treatment to use the whole plant, just not the isolated Cannabidiol CBD.(Source) Jason David, a parent treating his 7 year old son with epilepsy mentions in a report by ladybud.com that his son Jayden suffered from the wrong concentration of cannabinoids from the Charlotte's Web strain. He states:

“They’re not telling the whole truth,” says David. “There’s no way possible that all these children in Colorado could get seizure control and get off all their medications without using different ratios and adding THC and THCA (which are not allowed by the newly proposed legislation). Charlotte’s Web can work great in the beginning but it’s impossible to get off all the medications and go through benzo withdrawals without being able to play with the THC ratios.” (Source)

 
Source: http://time.com/3264691/medical-marijauna-epilepsy-research-charlottes-web-study/ http://onlinelibrary.wiley.com/doi/10.1111/epi.12610/abstract http://www.ladybud.com/2014/07/29/a-limited-amount-of-caring-parents-and-advocates-react-to-realm-of-carings-federal-cbd-only-bill/ http://theroc.us/index.php?option=com_k2&view=item&id=22:charlotte-s-web-medical-hemp-act-of-2014&Itemid=498

How Marijuana Effects GABA in the Nervous System

In short, GABA is a neurotransmitter in the mammal central nervous system that can repress excitability in the neurons in the nervous system and regulation in muscle tone. GABA is an abbreviation for gamma-Aminobutyric Acid which is an amino acid, which are secondary to water to being the biggest component in cells, tissue and muscle that are critical to biosynthesis and being a neurotransmitter. Cannabis plays a crucial role with the endocannabinoid system in suppressing the GABA, aiding in increasing dopamine levels which can help in treatments with medical marijuana.

GABA acts differently in stages of life, playing a roll in the developing brain as an excitatory component in the brain, while in adulthood acting as an inhibition in the brain. GABA regulates embryonic and neural stem cell growth. GABA has been found in the intestine, stomach, pancreas, fallopian tubes, uterus, ovaries, testis, kidney, bladder, lung, liver, lungs, melatonin and eye lens.(Source)

GABA makes up 40% of nerve cells, where glutamate makes up 30%. Glutamate offers excitability to the nervous system and also the brain synthesizes glutamate into GABA, which regulates the excitability, causing a check and balance, or ying and yang effect of controlling the functions. GABA inhibits nerve cells from growing, aggressive behavior, and regulates hyperactivity. (Source)

How Marijuana Inhibits GABA

Marijuana use effects the neurotransmitter GABA by blocking it. The result is increasing dopamine levels which normally GABA inhibits or regulates. Dopamine offers a mood shift of reward for the brain that is released with sex, exercise, appetite, learning, sleep, movement and mood.(Source)

Cannabis effects the cannabinoid receptors, namely Cb1 and Cb2 that mimic a naturally created endogenous molecule, anadamide. Anadamide is an Omega 6 fatty acid that regulates appetite, cognition, emotion, memory, mood and pain. Delta-9-tetrahydrocannabinol (THC) and other Cannabinoids found in marijuana can effect anadamide and therefore effect the endocannabinoid central nervous system.

THC, for instance, binds to the CB1 receptors, which reduces the enzyme cAMP which results in less protein kinase A. This results in potassium and calcium channels that ends up reducing the amount of neurotransmitters being released. This chemical reaction is the result of reducing GABA. A reduction in GABA results in an increase in dopamine. Dopamine do not effect the CB1 receptors. (Source)

Treatments From Inhibiting GABA

Research is still needed for more conclusive results, but promising studies and theories show that cannabis can be an effective treatment for it's ability to effect GABA including:

• Tinnitus – A brain induced ringing in the ear.

• Fibromyalgia – Tenderness in joints, muscles and other soft tissues.

• Anxiety – Stress inducing fear, unease and worry.

• Addiction – The difficulty to stop using substances.

• Schizophrenia – Difficulty knowing what is real and not, thinking clearly to have normal responses.

Source:

http://en.wikipedia.org/wiki/Gamma-Aminobutyric_acid

http://www.leafscience.com/2014/05/10/marijuana-dopamine-science/

http://countyourculture.com/tag/gaba/

http://thebrain.mcgill.ca/flash/i/i_03/i_03_m/i_03_m_par/i_03_m_par_cannabis.html

Sweet OG

Sweet OG

Sweet OG is a cross between Sweet Tooth and OG Kush. Sweet and citrus it is a taste that is like a lemon drop. A hybrid of both sativa like euphoric effects and indica heavy sedation effects. Starting with a head high it slowly takes effect into the over body relaxation. It is recommended for an after work or night time strain for it's ability to make you completely relaxed.

OUTCO.com offers a variety of strains, contact us today for more information on ordering.

Source:

http://www.leafly.com/hybrid/sweet-kush